Linked Life Data

7865461

Source:http://linkedlifedata.com/resource/pubmed/id/7865461

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1995-3-30
pubmed:abstractText
Mice with a drastic mutation in the terminal deoxynucleotidyl transferase (TdT) gene have recently been engineered. Igs and TCRs in these mice are essentially devoid of N-region diversity. Here we report that TdT0 mice contain elevated numbers of CD3hi single-positive (SP) thymocytes because more thymocytes make the transition from the immature double-positive to the mature SP stage. This suggests that the repertoire of TCRs encoded in the germline may be enriched for specificities capable of interacting with MHC molecules and that the loss of some of this affinity is the price paid for TdT-generated diversity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0953-8178
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1681-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
More efficient positive selection of thymocytes in mice lacking terminal deoxynucleotidyl transferase.
pubmed:affiliation
Laboratoire de Génétique Moléculaire des Eucaryotes, du CNRS, U184 de l'INSERM, Strasbourg, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't