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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1995-3-20
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pubmed:abstractText |
The human T-cell leukemia virus type I Tax protein trans-activates several cellular genes implicated in T-cell replication and activation. To investigate its leukemogenic potential, Tax was targeted to the mature T-lymphocyte compartment in transgenic mice by using the human granzyme B promoter. These mice developed large granular lymphocytic leukemia, demonstrating that expression of Tax in the lymphocyte compartment is sufficient for the development of leukemia. Furthermore, these observations suggest that human T-cell leukemia virus infection may be involved in the development of large granular lymphocytic leukemia.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-1355373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-1460293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-1461648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-1543158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-1624585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-1761544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-1873809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-1887217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-1895396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-2007574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-2072456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-2677310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-2689863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-2724422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-2740212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-2843985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-2847164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-2863442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-2887587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-2888190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-2888191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-2892860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-3074960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-3490993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-6328324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-8217341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7862633-8324214
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
92
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pubmed:geneSymbol |
tax
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1057-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7862633-Animals,
pubmed-meshheading:7862633-Base Sequence,
pubmed-meshheading:7862633-Cell Compartmentation,
pubmed-meshheading:7862633-DNA Probes,
pubmed-meshheading:7862633-Genes, pX,
pubmed-meshheading:7862633-Granzymes,
pubmed-meshheading:7862633-Human T-lymphotropic virus 1,
pubmed-meshheading:7862633-Humans,
pubmed-meshheading:7862633-Leukemia, Experimental,
pubmed-meshheading:7862633-Male,
pubmed-meshheading:7862633-Mice,
pubmed-meshheading:7862633-Mice, Transgenic,
pubmed-meshheading:7862633-Molecular Sequence Data,
pubmed-meshheading:7862633-Promoter Regions, Genetic,
pubmed-meshheading:7862633-Serine Endopeptidases,
pubmed-meshheading:7862633-T-Lymphocytes
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pubmed:year |
1995
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pubmed:articleTitle |
Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.
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pubmed:affiliation |
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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