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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8948
|
pubmed:dateCreated |
1995-3-17
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pubmed:abstractText |
A patient with follicular lymphoma developed a striking but transient plasmacytosis in blood and bone marrow with paraproteinaemia after treatment by autologous bone marrow transplantation and interleukin-3 (IL-3). By immunophenotyping, cytogenetics and Southern blotting, we proved that the plasma cells were clonally related to the original lymphoma cells. This event was preceded by fever accompanied by high IL-6 concentrations. The patient recovered spontaneously and had a long-lasting remission. We speculate that the bone marrow-derived malignant B cells were stimulated by IL-3 and IL-6 into terminally differentiated plasma cells.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0140-6736
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
25
|
pubmed:volume |
345
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
488-90
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7861876-Adult,
pubmed-meshheading:7861876-B-Lymphocytes,
pubmed-meshheading:7861876-Bone Marrow,
pubmed-meshheading:7861876-Bone Marrow Transplantation,
pubmed-meshheading:7861876-Cell Differentiation,
pubmed-meshheading:7861876-Female,
pubmed-meshheading:7861876-Humans,
pubmed-meshheading:7861876-Interleukin-3,
pubmed-meshheading:7861876-Interleukin-6,
pubmed-meshheading:7861876-Lymphoma, Follicular,
pubmed-meshheading:7861876-Transplantation, Autologous
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pubmed:year |
1995
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pubmed:articleTitle |
Differentiation of follicular lymphoma cells after autologous bone marrow transplantation and haematopoietic growth factor treatment.
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pubmed:affiliation |
Department of Pathology, University Medical Centre, Leiden, Netherlands.
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pubmed:publicationType |
Journal Article,
Case Reports
|