| pubmed-article:7861550 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7861550 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7861550 | lifeskim:mentions | umls-concept:C0025932 | lld:lifeskim |
| pubmed-article:7861550 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:7861550 | lifeskim:mentions | umls-concept:C0007134 | lld:lifeskim |
| pubmed-article:7861550 | lifeskim:mentions | umls-concept:C0020437 | lld:lifeskim |
| pubmed-article:7861550 | lifeskim:mentions | umls-concept:C0070099 | lld:lifeskim |
| pubmed-article:7861550 | lifeskim:mentions | umls-concept:C0021102 | lld:lifeskim |
| pubmed-article:7861550 | pubmed:issue | 3 Pt 1 | lld:pubmed |
| pubmed-article:7861550 | pubmed:dateCreated | 1995-3-20 | lld:pubmed |
| pubmed-article:7861550 | pubmed:abstractText | Humoral hypercalcemia of malignancy is a paraneoplastic syndrome believed to be due to production by the tumor of substances that stimulate osteoclastic bone resorption primarily. The human renal cell carcinoma cell line RC-8, grown in nude mice, was investigated for factors involved in renal cancer-induced hypercalcemia. At a tumor load of 200 to 400 mm.3 the mice developed hypercalcemia and hypophosphatemia associated with a rise in serum 1,25-dihydroxyvitamin D concentration and cachexia. The tumor released 1) significant amounts of human interleukin-6 (IL-6) and 2) parathyroid hormone-related peptide (PTHrP) into the circulation. Cancer cells further expressed mRNA for both human IL-6 and PTHrP. No secretion of human tumor necrosis factor-alpha or interleukin-1 beta could be demonstrated in the circulation of the host. Antibodies to IL-6 caused a significant (p = 0.043) inhibition of tumor growth and decreased serum calcium concentrations compared with control animals. Our data suggest that IL-6 is involved, either directly or indirectly, in the development of hypercalcemia in renal cell carcinoma. | lld:pubmed |
| pubmed-article:7861550 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7861550 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7861550 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7861550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7861550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7861550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7861550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7861550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7861550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7861550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7861550 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7861550 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7861550 | pubmed:issn | 0022-5347 | lld:pubmed |
| pubmed-article:7861550 | pubmed:author | pubmed-author:KurthK HKH | lld:pubmed |
| pubmed-article:7861550 | pubmed:author | pubmed-author:PapapoulosSS | lld:pubmed |
| pubmed-article:7861550 | pubmed:author | pubmed-author:LöwikCC | lld:pubmed |
| pubmed-article:7861550 | pubmed:author | pubmed-author:VosPP | lld:pubmed |
| pubmed-article:7861550 | pubmed:author | pubmed-author:SchamhartDD | lld:pubmed |
| pubmed-article:7861550 | pubmed:author | pubmed-author:WeissglasMM | lld:pubmed |
| pubmed-article:7861550 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7861550 | pubmed:volume | 153 | lld:pubmed |
| pubmed-article:7861550 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7861550 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7861550 | pubmed:pagination | 854-7 | lld:pubmed |
| pubmed-article:7861550 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7861550 | pubmed:meshHeading | pubmed-meshheading:7861550-... | lld:pubmed |
| pubmed-article:7861550 | pubmed:meshHeading | pubmed-meshheading:7861550-... | lld:pubmed |
| pubmed-article:7861550 | pubmed:meshHeading | pubmed-meshheading:7861550-... | lld:pubmed |
| pubmed-article:7861550 | pubmed:meshHeading | pubmed-meshheading:7861550-... | lld:pubmed |
| pubmed-article:7861550 | pubmed:meshHeading | pubmed-meshheading:7861550-... | lld:pubmed |
| pubmed-article:7861550 | pubmed:meshHeading | pubmed-meshheading:7861550-... | lld:pubmed |
| pubmed-article:7861550 | pubmed:meshHeading | pubmed-meshheading:7861550-... | lld:pubmed |
| pubmed-article:7861550 | pubmed:meshHeading | pubmed-meshheading:7861550-... | lld:pubmed |
| pubmed-article:7861550 | pubmed:meshHeading | pubmed-meshheading:7861550-... | lld:pubmed |
| pubmed-article:7861550 | pubmed:meshHeading | pubmed-meshheading:7861550-... | lld:pubmed |
| pubmed-article:7861550 | pubmed:meshHeading | pubmed-meshheading:7861550-... | lld:pubmed |
| pubmed-article:7861550 | pubmed:meshHeading | pubmed-meshheading:7861550-... | lld:pubmed |
| pubmed-article:7861550 | pubmed:meshHeading | pubmed-meshheading:7861550-... | lld:pubmed |
| pubmed-article:7861550 | pubmed:meshHeading | pubmed-meshheading:7861550-... | lld:pubmed |
| pubmed-article:7861550 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7861550 | pubmed:articleTitle | Hypercalcemia and cosecretion of interleukin-6 and parathyroid hormone related peptide by a human renal cell carcinoma implanted into nude mice. | lld:pubmed |
| pubmed-article:7861550 | pubmed:affiliation | Department of Urology, University Hospital of Leiden, The Netherlands. | lld:pubmed |
| pubmed-article:7861550 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7861550 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7861550 | lld:pubmed |
