| pubmed-article:7861120 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7861120 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:7861120 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7861120 | lifeskim:mentions | umls-concept:C0035316 | lld:lifeskim |
| pubmed-article:7861120 | lifeskim:mentions | umls-concept:C0068563 | lld:lifeskim |
| pubmed-article:7861120 | lifeskim:mentions | umls-concept:C0597879 | lld:lifeskim |
| pubmed-article:7861120 | lifeskim:mentions | umls-concept:C1621980 | lld:lifeskim |
| pubmed-article:7861120 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:7861120 | pubmed:dateCreated | 1995-3-20 | lld:pubmed |
| pubmed-article:7861120 | pubmed:abstractText | Retinal ganglion cells (RGCs) in rats were retrogradely labeled with the fluorescent tracer Fluorogold (FG) and subjected to GAP-43 and c-JUN immunocytochemistry to identify those RGCs that are capable of regenerating an axon. After optic nerve section (ONS) and simultaneous application of FG to the nerve stump (group 1 experiments), GAP-43 immunoreactive RGCs (between 2 and 21 days after ONS) always represented a subfraction of both FG-labeled (i.e., surviving) RGCs and RGCs exhibiting c-JUN. GAP-43 immunoreactive RGCs represented 22% of RGCs normally present in rat retinae and 25% of surviving RGCs at 5 days after ONS but were reduced to 2% and 1%, which is 6% and 5% of survivors at 14 and 21 days, respectively. In animals that received a peripheral nerve (PN) graft after ONS (group 2 experiments), RGCs with regenerating axons were identified by FG application to the graft at 14 and 21 days. When examined at 21 and 28 days, all FG-labeled RGCs exhibited GAP-43 immunoreactivity, and FG/GAP-43-labeled RGCs were 3% and 2% of those present in normal rat retinae. In relation to surviving RGCs GAP-43 immunoreactive RGCs represented 10% at both time points. FG-/GAP-43-labeled RGCs also exhibited c-JUN, but c-JUN immunoreactive RGCs were at both time points at least twice as numerous as FG-/GAP-43-labeled RGCs. These data suggest that regenerating axons in PN grafts derive specifically from GAP-43 reexpressing RGCs. Appearance of GAP-43 immunoreactivity may therefore identify those RGCs that are capable of axonal regeneration or sprouting. | lld:pubmed |
| pubmed-article:7861120 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7861120 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7861120 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7861120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7861120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7861120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7861120 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7861120 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7861120 | pubmed:issn | 0022-3034 | lld:pubmed |
| pubmed-article:7861120 | pubmed:author | pubmed-author:BährMM | lld:pubmed |
| pubmed-article:7861120 | pubmed:author | pubmed-author:StuermerC ACA | lld:pubmed |
| pubmed-article:7861120 | pubmed:author | pubmed-author:SchadenHH | lld:pubmed |
| pubmed-article:7861120 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7861120 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:7861120 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7861120 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7861120 | pubmed:pagination | 1570-8 | lld:pubmed |
| pubmed-article:7861120 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7861120 | pubmed:meshHeading | pubmed-meshheading:7861120-... | lld:pubmed |
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| pubmed-article:7861120 | pubmed:meshHeading | pubmed-meshheading:7861120-... | lld:pubmed |
| pubmed-article:7861120 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7861120 | pubmed:articleTitle | GAP-43 immunoreactivity and axon regeneration in retinal ganglion cells of the rat. | lld:pubmed |
| pubmed-article:7861120 | pubmed:affiliation | Faculty of Biology, University of Konstanz, Germany. | lld:pubmed |
| pubmed-article:7861120 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7861120 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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