Linked Life Data

7860761

Source:http://linkedlifedata.com/resource/pubmed/id/7860761

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-3-20
pubmed:abstractText
Hepatic glycogen concentration was measured in six subjects with insulin-dependent diabetes mellitus (IDDM) and nine weight-matched control subjects using 13C nuclear magnetic resonance spectroscopy during a day in which three isocaloric mixed meals were ingested. The relative fluxes of the direct and indirect (3 carbon units-->-->glycogen) pathways of hepatic glycogen synthesis were also assessed using [1-13C]glucose in combination with acetaminophen to noninvasively sample the hepatic UDP-glucose pool. Mean fasting hepatic glycogen content was similar in the two groups. After each meal, hepatic glycogen content increased, peaking 4-5 h after the meal in both groups. By 11:00 p.m. the IDDM subjects had synthesized only 30% of the glycogen that was synthesized by the control group [IDDM subjects, net increment = 44 +/- 20 (mean +/- SE) mM; control subjects, net increment = 144 +/- 14 mM; P < 0.05]. After breakfast the flux through the gluconeogenic pathway relative to the direct pathway of hepatic glycogen synthesis was 1.7-fold greater in the IDDM subjects (59 +/- 4%) than in the control subjects (35 +/- 4%, P < 0.0003). In conclusion, under mixed meal conditions, subjects with poorly controlled IDDM have a major defect in net hepatic glycogen synthesis and augmented hepatic gluconeogenesis. The former abnormality may result in an impaired glycemic response to counterregulatory hormones, whereas both abnormalities may contribute to postprandial hyperglycemia.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-1269837, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-1401068, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-1499856, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-1532777, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-1864968, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-1948033, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-2035629, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-2205106, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-2669515, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-2767340, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-3391341, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-3611353, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-4816891, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-6110598, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-6472448, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-6614167, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-6863277, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-7859939, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-8203517, http://linkedlifedata.com/resource/pubmed/commentcorrection/7860761-8227065
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
783-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study.
pubmed:affiliation
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Research Support, U.S. Gov't, P.H.S., Controlled Clinical Trial, Research Support, Non-U.S. Gov't