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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1995-3-21
|
| pubmed:abstractText |
HIV dementia has an annual incidence of 7% after AIDS development and eventually affects 20% of all HIV-infected persons. Accurate and early diagnosis of HIV dementia can lead to optimized therapeutic and management decisions. The purpose of this study was to design a valid instrument to identify HIV dementia. Five groups totalling 152 outpatients were evaluated; HIV-seronegative (SN) (n = 34); asymptomatic HIV-seropositive (ASX) (n = 38); AIDS, nondemented (AIDS) (n = 53); AIDS, mildly demented (Dm) (n = 39); and AIDS, severely demented (Ds) (n = 7). None had CNS opportunistic infections or delirium due to drug intoxication or systemic illness at the time of testing. Patients were evaluated with three different screening instruments: (a) the newly developed HIV Dementia Scale (HDS), (b) the Minimental State Exam (MMSE), and (c) the Grooved Pegboard (PB). Mean HDS scores (+/- SD) (maximum = 16) for each group were as follows: SN, 14.9 +/- 1.69; ASX, 14.1 +/- 1.72; AIDS, 12.8 +/- 3.17; Dm, 8.0 +/- 3.81; and Ds, 3.5 +/- 2.94. A Receiver-Operating Characteristic curve was used to derive an optimal HDS cut-off score of < or = 10 for identifying HIV dementia, with a sensitivity of 80%, specificity 91%, and positive predictive value 78%. The efficiencies of each instrument for identifying HIV dementia were as follows: HDS-84%, PB-86%, and MMSE-72%. The HDS is a reliable and quantitative scale that is superior to other widely used bedside tests such as the MMSE for identifying HIV dementia.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1077-9450
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
273-8
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7859139-AIDS Dementia Complex,
pubmed-meshheading:7859139-Adult,
pubmed-meshheading:7859139-Analysis of Variance,
pubmed-meshheading:7859139-Attention,
pubmed-meshheading:7859139-Female,
pubmed-meshheading:7859139-Humans,
pubmed-meshheading:7859139-Linear Models,
pubmed-meshheading:7859139-Male,
pubmed-meshheading:7859139-Memory,
pubmed-meshheading:7859139-Psychomotor Performance,
pubmed-meshheading:7859139-ROC Curve,
pubmed-meshheading:7859139-Risk Factors,
pubmed-meshheading:7859139-Sensitivity and Specificity
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
HIV Dementia Scale: a rapid screening test.
|
| pubmed:affiliation |
Department of Neurology, Johns Hopkins University, Baltimore, Maryland.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|