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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-3-15
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pubmed:databankReference |
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pubmed:abstractText |
Sequencing and computer analysis of a variola major virus strain India-1967 (VAR-IND) genome segment (53,018 bp) from the right terminal region has been carried out. Fifty-nine potential open reading frames (ORFs) of over 60 amino acid residues were identified. Structure-function organization of the VAR-IND DNA segment was compared with the previously reported sequences from the analogous genomic regions of vaccinia virus strains Copenhagen (VAC-COP) and Western Reserve (VAC-WR) and variola virus strain Harvey (VAR-HAR). Multiple differences between VAR-IND and the strains of VAC but the high identity of VAR-IND with VAR-HAR in the genetic maps are revealed. Possible functions of the predicted viral proteins and the effect of their differences on the features of orthopoxviruses are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0168-1702
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
207-36
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7856312-Amino Acid Sequence,
pubmed-meshheading:7856312-Animals,
pubmed-meshheading:7856312-DNA, Viral,
pubmed-meshheading:7856312-Genes, Viral,
pubmed-meshheading:7856312-Genome, Viral,
pubmed-meshheading:7856312-Humans,
pubmed-meshheading:7856312-Membrane Glycoproteins,
pubmed-meshheading:7856312-Mice,
pubmed-meshheading:7856312-Molecular Sequence Data,
pubmed-meshheading:7856312-Open Reading Frames,
pubmed-meshheading:7856312-Rats,
pubmed-meshheading:7856312-Receptors, Cytokine,
pubmed-meshheading:7856312-Restriction Mapping,
pubmed-meshheading:7856312-Sequence Analysis, DNA,
pubmed-meshheading:7856312-Sequence Homology, Amino Acid,
pubmed-meshheading:7856312-Serine Proteinase Inhibitors,
pubmed-meshheading:7856312-Vaccinia virus,
pubmed-meshheading:7856312-Variola virus,
pubmed-meshheading:7856312-Viral Proteins
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pubmed:year |
1994
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pubmed:articleTitle |
Analysis of the nucleotide sequence of 53 kbp from the right terminus of the genome of variola major virus strain India-1967.
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pubmed:affiliation |
Institute of Molecular Biology, Russian State Research Center NPO Vector, Koltsovo, Novosibirsk region.
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pubmed:publicationType |
Journal Article
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