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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1995-3-15
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pubmed:abstractText |
Markers of immune stimulation were studied in 76 sequential cerebrospinal fluid (CSF) samples from 19 patients infected with HIV-1 without antiretroviral treatment during observation periods ranging from 22 months to 6 years. Eight of these patients were further followed with 14 CSF samples for 3-24 months of zidovudine treatment. During the course of HIV-1 infection, the mean CSF neopterin and beta 2-microglobulin (beta 2M) concentrations increased from 12.7 to 20.4 nmol/l (p < 0.01) and from 1.93 to 2.17 mg/l (p < 0.05), respectively, while the mean peripheral CD4 + T cell count decreased from 624 to 320 cells x 10(6)/l (p < 0.001). The IgG index, reflecting intrathecal immunoglobulin production, increased from 0.72 to 0.92 (p = 0.08). The number of patients with CSF pleocytosis did not change significantly during follow-up (8/19 at baseline, 7/19 at endpoint). In the 8 patients followed up during antiretroviral treatment, a significant reduction in mean CSF levels of neopterin and beta 2M (-48% and -32%, respectively, p < 0.01) was seen after 3-12 months on zidovudine. We suggest that gradual increase in immune stimulation reflected by the rising CSF concentrations of neopterin and beta 2M indicates that HIV-1 infection in the central nervous system is progressive even in neurologically asymptomatic stages.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Biopterin,
http://linkedlifedata.com/resource/pubmed/chemical/Neopterin,
http://linkedlifedata.com/resource/pubmed/chemical/Zidovudine,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Microglobulin
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pubmed:status |
MEDLINE
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pubmed:issn |
0036-5548
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
523-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7855550-Adult,
pubmed-meshheading:7855550-Aged,
pubmed-meshheading:7855550-Biological Markers,
pubmed-meshheading:7855550-Biopterin,
pubmed-meshheading:7855550-Female,
pubmed-meshheading:7855550-HIV Infections,
pubmed-meshheading:7855550-HIV Seropositivity,
pubmed-meshheading:7855550-HIV-1,
pubmed-meshheading:7855550-Humans,
pubmed-meshheading:7855550-Longitudinal Studies,
pubmed-meshheading:7855550-Male,
pubmed-meshheading:7855550-Middle Aged,
pubmed-meshheading:7855550-Monitoring, Immunologic,
pubmed-meshheading:7855550-Neopterin,
pubmed-meshheading:7855550-Zidovudine,
pubmed-meshheading:7855550-beta 2-Microglobulin
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pubmed:year |
1994
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pubmed:articleTitle |
Markers of immune stimulation in the cerebrospinal fluid during HIV infection: a longitudinal study.
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pubmed:affiliation |
Department of Infectious Diseases, University of Göteborg, Sweden.
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pubmed:publicationType |
Journal Article,
Comparative Study
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