Linked Life Data

7854452

Source:http://linkedlifedata.com/resource/pubmed/id/7854452

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6516
pubmed:dateCreated
1995-3-16
pubmed:abstractText
Polypeptide growth factors are important effectors of cell growth and differentiation in vitro and are thought to be critical for processes such as specification of cell fate, tissue growth and organogenesis in vivo. Scatter factor/hepatocyte growth factor (SF/HGF) is the prototype of an emerging family of growth factors that resemble in their domain structure and mechanism of activation the blood proteinase plasminogen. The cellular responses of SF/HGF are mediated by the c-Met tyrosine kinase receptor. Here we report that mice lacking SF/HGF fail to complete development and die in utero. The mutation affects the embryonic liver, which is reduced in size and shows extensive loss of parenchymal cells. In addition, development of the placenta, particularly of trophoblast cells, is impaired. Thus, SF/HGF is essential for the development of several epithelial organs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
373
pubmed:geneSymbol
HGF
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
699-702
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Scatter factor/hepatocyte growth factor is essential for liver development.
pubmed:affiliation
Max-Delbrück Laboratorium in der Max-Planck-Gesellschaft, Köln, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't