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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1995-3-16
|
| pubmed:abstractText |
Propofol and isoflurane were compared for haemodynamic stability and recovery time as main anaesthetic agents for maintenance in a total of 43 ASA I and II patients in uncomplicated operations lasting at least 30 min. The premedication (oral diazepam), induction (thiopentone-fentanyl-suxamethonium) and maintenance protocol (N2O-O2 2:1 litre min-1, fentanyl and vecuronium in incremental doses) were identical for all patients. In one group of 20 patients, propofol was used in continuous intravenous (i.v.) infusion (starting dose 3 mg kg-1 h-1), while in the second group of 23 patients, isoflurane was administered in a starting concentration of 1%. To improve the equipotency of the two agents in all cases the dose of the main anaesthetic was titrated to keep the EEG 90% spectral edge frequency (SEF-recorded by processed EEG monitor) between 8 and 12 Hz. Mean blood pressure (BP) and heart rate (HR) deviations of +/- 20% from the baseline were recorded. The incidence of mean blood pressure deviations/case in the propofol group was less than half of those occurring in the isoflurane group (0.45 vs. 0.96 P = 0.04). The mean duration of blood pressure deviation from baseline value was 5.5 min in the propofol group vs. 16.8 min in the isoflurane group (P = 0.01). The recovery intervals were significantly shorter in the propofol group (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0265-0215
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
443-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7851350-Adolescent,
pubmed-meshheading:7851350-Adult,
pubmed-meshheading:7851350-Aged,
pubmed-meshheading:7851350-Anesthesia, General,
pubmed-meshheading:7851350-Anesthesia, Inhalation,
pubmed-meshheading:7851350-Anesthesia, Intravenous,
pubmed-meshheading:7851350-Anesthesia Recovery Period,
pubmed-meshheading:7851350-Awareness,
pubmed-meshheading:7851350-Blood Pressure,
pubmed-meshheading:7851350-Cognition,
pubmed-meshheading:7851350-Electroencephalography,
pubmed-meshheading:7851350-Female,
pubmed-meshheading:7851350-Heart Rate,
pubmed-meshheading:7851350-Humans,
pubmed-meshheading:7851350-Isoflurane,
pubmed-meshheading:7851350-Male,
pubmed-meshheading:7851350-Memory,
pubmed-meshheading:7851350-Middle Aged,
pubmed-meshheading:7851350-Propofol,
pubmed-meshheading:7851350-Signal Processing, Computer-Assisted,
pubmed-meshheading:7851350-Therapeutic Equivalency
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Use of EEG spectral edge as index of equipotency in a comparison of propofol and isoflurane for maintenance of general anaesthesia.
|
| pubmed:affiliation |
Division of Anesthesiology, Ben-Gurion University of the Negev, Faculty of Health Sciences, Soroka Medical Center, Beer-Sheva, Israel.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Controlled Clinical Trial
|