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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1995-3-16
|
| pubmed:abstractText |
To investigate whether a resistance to insulin-stimulated glucose uptake (IR) is associated with the risk factors (RF) for cardiovascular disease (CVD) in non-insulin-dependent diabetic (NIDDM) patients, we determined the degree of IR in 135 adult NIDDM patients who had no advanced diabetic complications. The euglycemic (80 mg/dl) hyperinsulinemic clamp (insulin infusion rate 1.12 mU/kg per min) was performed and the average glucose infusion rate (GIR) during a steady-state euglycemia was determined as a measure of IR. Hypertension was more common among NIDDM patients with an increased IR and was highest in the group of patients with CVD. CVD-RF such as hypertension, hypertriglyceridemia, low HDL-cholesterol and obesity tended to cluster in the NIDDM patients who had lower GIR values and higher fasting IRI levels. GIR values were compared between a set of groups extracted from the 135 NIDDM patients that were matched for age, sex, body mass index and HbA1c levels. The CVD-positive group had the significantly lower GIR value than the CVD-negative group (2.06 +/- 0.66 vs. 3.45 +/- 1.75, P < 0.005). The GIR value was also significantly lower in the hypertriglyceridemic group compared with the normotriglyceridemic group (2.50 +/- 1.36 vs. 4.03 +/- 1.82, P < 0.0005). However, there was no significant difference between the hypertensive and normotensive groups and between the high cholesterol or low HDL-cholesterol groups and their respective control groups. In conclusion, these results suggest that IR contributes to the clustering of CVD-RFs which may accelerate the development of CVD in the subgroup of Japanese NIDDM patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, VLDL,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0168-8227
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
191-8
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7851274-Adult,
pubmed-meshheading:7851274-Aged,
pubmed-meshheading:7851274-Apolipoproteins,
pubmed-meshheading:7851274-Cardiovascular Diseases,
pubmed-meshheading:7851274-Cholesterol,
pubmed-meshheading:7851274-Cholesterol, HDL,
pubmed-meshheading:7851274-Cholesterol, LDL,
pubmed-meshheading:7851274-Diabetes Mellitus,
pubmed-meshheading:7851274-Diabetes Mellitus, Type 2,
pubmed-meshheading:7851274-Diabetic Angiopathies,
pubmed-meshheading:7851274-Female,
pubmed-meshheading:7851274-Humans,
pubmed-meshheading:7851274-Hypertension,
pubmed-meshheading:7851274-Insulin,
pubmed-meshheading:7851274-Insulin Resistance,
pubmed-meshheading:7851274-Japan,
pubmed-meshheading:7851274-Lipoproteins, VLDL,
pubmed-meshheading:7851274-Male,
pubmed-meshheading:7851274-Middle Aged,
pubmed-meshheading:7851274-Obesity,
pubmed-meshheading:7851274-Prevalence,
pubmed-meshheading:7851274-Risk Factors,
pubmed-meshheading:7851274-Triglycerides
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Relationship between insulin resistance and risk factors for cardiovascular disease in Japanese non-insulin-dependent diabetic patients.
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| pubmed:affiliation |
Diabetes Center, Tokyo Women's Medical College, Japan.
|
| pubmed:publicationType |
Journal Article
|