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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1995-3-13
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pubmed:abstractText |
Concentrations of serum phosphate and parathyroid hormone (PTH) are well known regulators of the production of 1,25-dihydroxyvitamin D (1,25-(OH)2D) and acidosis is known to affect the serum concentration of 1,25-(OH)2D. However, the factors that play a role in the regulation of serum 1,25-(OH)2D concentration in healthy subjects have not been fully evaluated. The associations of ionised calcium, pH, serum concentration of phosphate, PTH, 25-hydroxyvitamin D (25-OHD) and serum 1,25-(OH)2D were examined in 296 healthy premenopausal women (age range 17-40 years). Calculation of partial correlation coefficients showed that serum 1,25-(OH)2D was significantly correlated with phosphate (r = -0.148, P < 0.01), pH (r = 0.221, P < 0.001) and PTH (r = 0.136. P < 0.01). Ionised calcium was not related to serum 1,25-(OH)2D. When the results were stratified according to quartiles based on serum 1,25-(OH)2D concentration, significant trends (by analysis of variance) were seen in phosphate, pH, age, albumin and 25-OHD. Stepwise multiple regression analysis showed that phosphate and pH were the major contributors of serum 1,25-(OH)2D levels. There was a small contribution from PTH and 25-OHD. The results suggest that in young healthy premenopausal women plasma phosphate and pH may be important determinants of serum 1,25-(OH)2D concentration.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium, Dietary,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydroxycholecalciferols,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0009-8981
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
230
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7850990-Adolescent,
pubmed-meshheading:7850990-Adult,
pubmed-meshheading:7850990-Aging,
pubmed-meshheading:7850990-Calcium,
pubmed-meshheading:7850990-Calcium, Dietary,
pubmed-meshheading:7850990-Cross-Sectional Studies,
pubmed-meshheading:7850990-Dihydroxycholecalciferols,
pubmed-meshheading:7850990-Female,
pubmed-meshheading:7850990-Humans,
pubmed-meshheading:7850990-Parathyroid Hormone,
pubmed-meshheading:7850990-Phosphates,
pubmed-meshheading:7850990-Premenopause,
pubmed-meshheading:7850990-Reference Values,
pubmed-meshheading:7850990-Serum Albumin
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pubmed:year |
1994
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pubmed:articleTitle |
Determinants of serum 1,25-dihydroxyvitamin D concentration in healthy premenopausal subjects.
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pubmed:affiliation |
Department of Community and Family Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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