| pubmed-article:7850477 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7850477 | lifeskim:mentions | umls-concept:C0003018 | lld:lifeskim |
| pubmed-article:7850477 | lifeskim:mentions | umls-concept:C0034787 | lld:lifeskim |
| pubmed-article:7850477 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:7850477 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:7850477 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:7850477 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:7850477 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:7850477 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:7850477 | lifeskim:mentions | umls-concept:C0103306 | lld:lifeskim |
| pubmed-article:7850477 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7850477 | pubmed:dateCreated | 1995-3-15 | lld:pubmed |
| pubmed-article:7850477 | pubmed:abstractText | In this study we describe a new angiotensin antagonist [Asp1-Arg2-Val3-Tyr4-Ile5-His6-D-Ala7, (A-779)] selective for the heptapeptide angiotensin-(1-7) [Ang-(1-7)]. A-779 blocked the antidiuretic effect of Ang-(1-7) in water-loaded rats and the changes in blood pressure produced by Ang-(1-7) microinjection into the dorsal-medial and ventrolateral medulla. In contrast, A-779 did not change the dipsogenic, pressor, or myotropic effects of angiotensin II (Ang II). Also, A-779 did not affect the antidiuretic effect of vasopressin or the contractile effects of angiotensin III, bradykinin, or substance P on the rat ileum. In the rostral ventrolateral medulla, the pressor effect produced by Ang-(1-7) microinjection was completely blocked by A-779 but not by AT1 or AT2 receptor antagonists (DUP 753 and CGP 42112A, respectively). Conversely, the pressor effect produced by Ang II was not changed by A-779 but was completely blocked by DUP 753. Binding studies substantiated these observations: A-779 did not compete significantly for 125I-Ang II binding to adrenocortical membranes at up to a 1 microM concentration. Low affinity binding was also observed in adrenomedullary membranes with an IC50 greater than 10 microM. Our results show that A-779 is a potent and selective antagonist for Ang-(1-7). More importantly, our data indicate that specific angiotensin receptors mediate the central and peripheral actions of Ang-(1-7). | lld:pubmed |
| pubmed-article:7850477 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7850477 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7850477 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7850477 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7850477 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7850477 | pubmed:issn | 0361-9230 | lld:pubmed |
| pubmed-article:7850477 | pubmed:author | pubmed-author:SilvaL CLC | lld:pubmed |
| pubmed-article:7850477 | pubmed:author | pubmed-author:RodriguesA... | lld:pubmed |
| pubmed-article:7850477 | pubmed:author | pubmed-author:SantosR ARA | lld:pubmed |
| pubmed-article:7850477 | pubmed:author | pubmed-author:BarachoN CNC | lld:pubmed |
| pubmed-article:7850477 | pubmed:author | pubmed-author:Campagnole-Sa... | lld:pubmed |
| pubmed-article:7850477 | pubmed:author | pubmed-author:FontesM AMA | lld:pubmed |
| pubmed-article:7850477 | pubmed:author | pubmed-author:NevesL ALA | lld:pubmed |
| pubmed-article:7850477 | pubmed:author | pubmed-author:OliveiraD RDR | lld:pubmed |
| pubmed-article:7850477 | pubmed:author | pubmed-author:CaligiorneS... | lld:pubmed |
| pubmed-article:7850477 | pubmed:author | pubmed-author:Gropen... | lld:pubmed |
| pubmed-article:7850477 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7850477 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:7850477 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7850477 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:7850477 | pubmed:pagination | 293-8 | lld:pubmed |
| pubmed-article:7850477 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7850477 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7850477 | pubmed:articleTitle | Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. | lld:pubmed |
| pubmed-article:7850477 | pubmed:affiliation | Departamento de Fisiologia e Biofísica, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. | lld:pubmed |
| pubmed-article:7850477 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7850477 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7850477 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7850477 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7850477 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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