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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1995-3-15
|
| pubmed:abstractText |
In this study we describe a new angiotensin antagonist [Asp1-Arg2-Val3-Tyr4-Ile5-His6-D-Ala7, (A-779)] selective for the heptapeptide angiotensin-(1-7) [Ang-(1-7)]. A-779 blocked the antidiuretic effect of Ang-(1-7) in water-loaded rats and the changes in blood pressure produced by Ang-(1-7) microinjection into the dorsal-medial and ventrolateral medulla. In contrast, A-779 did not change the dipsogenic, pressor, or myotropic effects of angiotensin II (Ang II). Also, A-779 did not affect the antidiuretic effect of vasopressin or the contractile effects of angiotensin III, bradykinin, or substance P on the rat ileum. In the rostral ventrolateral medulla, the pressor effect produced by Ang-(1-7) microinjection was completely blocked by A-779 but not by AT1 or AT2 receptor antagonists (DUP 753 and CGP 42112A, respectively). Conversely, the pressor effect produced by Ang II was not changed by A-779 but was completely blocked by DUP 753. Binding studies substantiated these observations: A-779 did not compete significantly for 125I-Ang II binding to adrenocortical membranes at up to a 1 microM concentration. Low affinity binding was also observed in adrenomedullary membranes with an IC50 greater than 10 microM. Our results show that A-779 is a potent and selective antagonist for Ang-(1-7). More importantly, our data indicate that specific angiotensin receptors mediate the central and peripheral actions of Ang-(1-7).
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/7-Ala-angiotensin (1-7),
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Angiotensin,
http://linkedlifedata.com/resource/pubmed/chemical/angiotensin II (1-7)
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0361-9230
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
293-8
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7850477-Adrenal Glands,
pubmed-meshheading:7850477-Amino Acid Sequence,
pubmed-meshheading:7850477-Angiotensin II,
pubmed-meshheading:7850477-Animals,
pubmed-meshheading:7850477-Blood Pressure,
pubmed-meshheading:7850477-Diuresis,
pubmed-meshheading:7850477-Female,
pubmed-meshheading:7850477-Heart Rate,
pubmed-meshheading:7850477-Injections, Intraventricular,
pubmed-meshheading:7850477-Male,
pubmed-meshheading:7850477-Medulla Oblongata,
pubmed-meshheading:7850477-Molecular Sequence Data,
pubmed-meshheading:7850477-Muscle, Smooth,
pubmed-meshheading:7850477-Muscle Contraction,
pubmed-meshheading:7850477-Peptide Fragments,
pubmed-meshheading:7850477-Rats,
pubmed-meshheading:7850477-Rats, Wistar,
pubmed-meshheading:7850477-Receptors, Angiotensin,
pubmed-meshheading:7850477-Uterine Contraction
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors.
|
| pubmed:affiliation |
Departamento de Fisiologia e Biofísica, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|