| pubmed-article:7849320 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7849320 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7849320 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:7849320 | lifeskim:mentions | umls-concept:C1335268 | lld:lifeskim |
| pubmed-article:7849320 | lifeskim:mentions | umls-concept:C0014819 | lld:lifeskim |
| pubmed-article:7849320 | lifeskim:mentions | umls-concept:C0077503 | lld:lifeskim |
| pubmed-article:7849320 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:7849320 | lifeskim:mentions | umls-concept:C1420280 | lld:lifeskim |
| pubmed-article:7849320 | lifeskim:mentions | umls-concept:C1419030 | lld:lifeskim |
| pubmed-article:7849320 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:7849320 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:7849320 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7849320 | pubmed:dateCreated | 1995-3-16 | lld:pubmed |
| pubmed-article:7849320 | pubmed:abstractText | Two tumor necrosis factor receptors (TNFRs) with molecular weights of 55 kD (TNFR-p55) and 75 kD (TNFR-p75) have recently been identified and cloned. In previous studies, TNFR-p55 has been shown to exclusively mediate bidirectional effects of TNF-alpha on committed bone marrow granulocyte-macrophage progenitor cells, whereas both TNFR-p55 and TNFR-p75 can mediate inhibition of primitive progenitors requiring multiple cytokines to proliferate. We show here that TNF-alpha potently and directly inhibits the in vitro growth of committed erythroid progenitor cells in response to multiple cytokine combinations, and that TNF-alpha-induced inhibition of burst-forming unit-erythroid colony formation is mainly mediated through TNFR-p55, although TNFR-p75-mediated inhibition could be observed on progenitors responsive to erythropoietin alone. Moreover, at low TNF-alpha concentrations (2 ng/mL), TNF-alpha stimulates interleukin-3-dependent in vitro growth of committed granulocyte-macrophage progenitor cells, whereas it potently inhibits erythroid progenitor cell proliferation, showing that one concentration of TNF-alpha can simultaneously and bidirectionally modulate interleukin-3-dependent growth of committed granulocyte-macrophage (stimulation) and erythroid progenitor cells (inhibition). | lld:pubmed |
| pubmed-article:7849320 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7849320 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7849320 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7849320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7849320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7849320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7849320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7849320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7849320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7849320 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7849320 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:7849320 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:7849320 | pubmed:author | pubmed-author:JacobsenS ESE | lld:pubmed |
| pubmed-article:7849320 | pubmed:author | pubmed-author:RustenL SLS | lld:pubmed |
| pubmed-article:7849320 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7849320 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7849320 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:7849320 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7849320 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7849320 | pubmed:pagination | 989-96 | lld:pubmed |
| pubmed-article:7849320 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7849320 | pubmed:meshHeading | pubmed-meshheading:7849320-... | lld:pubmed |
| pubmed-article:7849320 | pubmed:meshHeading | pubmed-meshheading:7849320-... | lld:pubmed |
| pubmed-article:7849320 | pubmed:meshHeading | pubmed-meshheading:7849320-... | lld:pubmed |
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| pubmed-article:7849320 | pubmed:meshHeading | pubmed-meshheading:7849320-... | lld:pubmed |
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| pubmed-article:7849320 | pubmed:meshHeading | pubmed-meshheading:7849320-... | lld:pubmed |
| pubmed-article:7849320 | pubmed:meshHeading | pubmed-meshheading:7849320-... | lld:pubmed |
| pubmed-article:7849320 | pubmed:meshHeading | pubmed-meshheading:7849320-... | lld:pubmed |
| pubmed-article:7849320 | pubmed:meshHeading | pubmed-meshheading:7849320-... | lld:pubmed |
| pubmed-article:7849320 | pubmed:meshHeading | pubmed-meshheading:7849320-... | lld:pubmed |
| pubmed-article:7849320 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7849320 | pubmed:articleTitle | Tumor necrosis factor (TNF)-alpha directly inhibits human erythropoiesis in vitro: role of p55 and p75 TNF receptors. | lld:pubmed |
| pubmed-article:7849320 | pubmed:affiliation | Department of Immunology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo. | lld:pubmed |
| pubmed-article:7849320 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7849320 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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