Linked Life Data

7849261

Source:http://linkedlifedata.com/resource/pubmed/id/7849261

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-3-16
pubmed:abstractText
Steroid hormones are key regulatory molecules required for the coordinated regulation of the events associated with growth, differentiation and maintenance of cellular homeostasis. A large number of clinical abnormalities have been shown to be associated with defects in sex steroid hormone production or in the way the cell responds to these hormonal stimuli. As a consequence of the need to modulate the action of the sex steroids, several antihormones, compounds which oppose the action of the natural hormones, have been developed. These antihormones have found widespread application in the treatment of breast and prostate cancers, endometriosis and uterine fibroids. Of late, considerable progress has been made in defining the precise molecular mechanism of action of steroid hormones and their corresponding antihormones. It is anticipated that this information will impact the discovery and development of novel antihormones with improved therapeutic profiles.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1044-579X
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
327-36
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Definition of the cellular mechanisms which distinguish between hormone and antihormone activated steroid receptors.
pubmed:affiliation
Department of Pharmacology, Duke University Medical Center, Durham, NC 27710.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review