Linked Life Data

7849251

Source:http://linkedlifedata.com/resource/pubmed/id/7849251

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-3-16
pubmed:abstractText
The influence of gender and gonadectomy on (1) the density of the renal thiazide-sensitive ion transporter, as quantitated by the ability of renal membranes to bind (3H)metolazone, and (2) the changes in the urinary excretion of electrolytes caused by maximal bendroflumethiazide (BFTZ) in Sprague-Dawley rats was determined. The density of the thiazide receptor was twofold higher (P < 0.001) in females than in males. Orchiectomy increased thiazide receptor significantly in one of two studies (P < 0.01). Ovariectomy decreased thiazide receptor by more than 20% (P < 0.01) in both studies. The rates of the urinary excretion of sodium and chloride after BFTZ and the increases in the urinary excretion of sodium, chloride, and ammonium caused by BFTZ were greater in intact females than in intact males; BFTZ decreased the urinary excretion of calcium 50% in intact females, but not in intact males. Regression analysis of the thiazide receptor (in intact and gonadectomized animals) versus the urinary excretion of electrolytes before and after BFTZ yielded a model in which one-third of the variation in thiazide receptor could be related to the change in the excretion of calcium and ammonium produced by BFTZ, raising the possibility that the density of the thiazide receptor might be related to calcium or acid-base homeostasis. It was concluded that the renal excretion of sodium, chloride, calcium, and ammonium are, in part, controlled by gender and sex hormones via their regulation of the renal density of the thiazide diuretic receptor.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1046-6673
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1112-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:7849251-Animals, pubmed-meshheading:7849251-Bendroflumethiazide, pubmed-meshheading:7849251-Carrier Proteins, pubmed-meshheading:7849251-Diuresis, pubmed-meshheading:7849251-Diuretics, pubmed-meshheading:7849251-Female, pubmed-meshheading:7849251-Gonadal Steroid Hormones, pubmed-meshheading:7849251-Kidney, pubmed-meshheading:7849251-Male, pubmed-meshheading:7849251-Metolazone, pubmed-meshheading:7849251-Orchiectomy, pubmed-meshheading:7849251-Organ Size, pubmed-meshheading:7849251-Ovariectomy, pubmed-meshheading:7849251-Rats, pubmed-meshheading:7849251-Rats, Sprague-Dawley, pubmed-meshheading:7849251-Receptors, Drug, pubmed-meshheading:7849251-Sex Characteristics, pubmed-meshheading:7849251-Sodium Chloride Symporter Inhibitors, pubmed-meshheading:7849251-Sodium Chloride Symporters, pubmed-meshheading:7849251-Symporters
pubmed:year
1994
pubmed:articleTitle
Influence of gender on renal thiazide diuretic receptor density and response.
pubmed:affiliation
Department of Medicine, School of Medicine, University of California, San Diego, La Jolla 92093-0623.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.