Linked Life Data

7848512

Source:http://linkedlifedata.com/resource/pubmed/id/7848512

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-3-16
pubmed:abstractText
Hemorrhagic fever with renal syndrome is an acute viral disease caused by Hantavirus. On the basis of clinical observation, the illness is divided into five sequential stages: febrile, hypotensive, oliguric, diuretic, and convalescent. Because interferons can be induced by viruses, and because their stimulating effects on immune cells can alter the course of viral infections, we examined the presence of alpha interferon (IFN-alpha) and gamma interferon (IFN-gamma) in 276 serum samples collected from 110 patients during the Korean Conflict. We tested these sera for IFN-alpha by bioassay with bovine kidney MDBK cells, and for IFN-gamma by a sandwich ELISA with antibodies specific for human IFN-gamma. We found variable, but persistently elevated levels of IFN-gamma throughout the various phases of the disease, which suggested persistent immune activation through convalescence. Moderate levels of IFN-alpha were found in all stages of infection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0882-8245
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-101
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Serum levels of alpha and gamma interferons in hemorrhagic fever with renal syndrome.
pubmed:affiliation
Applied Research Division, USAMRIID, Ft. Detrick, Frederick, Maryland.
pubmed:publicationType
Journal Article