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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1995-3-7
|
| pubmed:abstractText |
This study was designed to examine haemodynamic and haematologic effects of the crown-of-thorns starfish venom (Acanthaster planci venom: APV) in dogs. Severe systemic hypotension, thrombocytopenia and leukopenia were induced by APV (1.0 mg protein/kg i.v.), followed by gradual return to the baseline level within 60 min. Hypotension was presumably caused by two factors: an early decrease in systemic vascular resistance and the large reduction in cardiac output due to reduced ventricular filling. Indomethacin, a cyclooxygenase inhibitor, remarkably suppressed systemic hypotension induced by APV. The peak reduction in systemic pressure was associated with concomitant rise of plasma 6-keto-PGF1 alpha, a major stable metabolite of prostacyclin. Thus, the hypotensive effect of APV may be caused primarily by prostacyclin and/or some vasodilating prostaglandins. In contrast, thrombocytopenia and leukopenia were not affected by cyclooxygenase inhibitor, 5-lipoxygenase inhibitor or platelet activating factor (PAF) receptor antagonist. When APV was administered repeatedly, tachyphylaxis was developed in haemodynamic effects, but not in haematologic effects. These findings suggest that APV-induced hypotensive effects may occur mainly through endogenous production of vasodilating prostaglandins including prostacyclin, although APV-induced thrombocytopenia and leukopenia may be caused by other mechanism(s) unrelated to arachidonate metabolites and/or PAF.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/6-Ketoprostaglandin F1 alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Activating Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Venoms
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0041-0101
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1217-25
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:7846692-6-Ketoprostaglandin F1 alpha,
pubmed-meshheading:7846692-Animals,
pubmed-meshheading:7846692-Blood Cells,
pubmed-meshheading:7846692-Blood Pressure,
pubmed-meshheading:7846692-Cardiac Output,
pubmed-meshheading:7846692-Cyclooxygenase Inhibitors,
pubmed-meshheading:7846692-Dogs,
pubmed-meshheading:7846692-Dose-Response Relationship, Drug,
pubmed-meshheading:7846692-Female,
pubmed-meshheading:7846692-Hemodynamics,
pubmed-meshheading:7846692-Hypotension,
pubmed-meshheading:7846692-Indomethacin,
pubmed-meshheading:7846692-Injections, Intravenous,
pubmed-meshheading:7846692-Leukopenia,
pubmed-meshheading:7846692-Lipoxygenase Inhibitors,
pubmed-meshheading:7846692-Male,
pubmed-meshheading:7846692-Platelet Activating Factor,
pubmed-meshheading:7846692-Starfish,
pubmed-meshheading:7846692-Tachyphylaxis,
pubmed-meshheading:7846692-Thrombocytopenia,
pubmed-meshheading:7846692-Vascular Resistance,
pubmed-meshheading:7846692-Venoms
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Haemodynamic and haematologic effects of Acanthaster planci venom in dogs.
|
| pubmed:affiliation |
Department of Pharmacology, School of Medicine, University of the Ryukyus, Okinawa, Japan.
|
| pubmed:publicationType |
Journal Article
|