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pubmed-article:7846628pubmed:abstractTextEndotoxin (lipopolysaccharide) stimulates transmembrane L-arginine transport in pulmonary artery endothelial cells (PAECs). The proinflammatory cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) mediate many of the pathophysiologic effects of endotoxemia and sepsis. Endothelial cells secrete TNF and IL-1 in response to endotoxin. We hypothesize that lipopolysaccharide stimulation of plasma membrane L-arginine transport is mediated via an autocrine cytokine loop involving TNF and IL-1.lld:pubmed
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pubmed-article:7846628pubmed:articleTitleCytokines regulate endotoxin stimulation of endothelial cell arginine transport.lld:pubmed
pubmed-article:7846628pubmed:affiliationDepartment of Surgery, University of Florida, Gainesville 32610-0286.lld:pubmed
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pubmed-article:7846628pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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