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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-3-6
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pubmed:abstractText |
Endotoxin (lipopolysaccharide) stimulates transmembrane L-arginine transport in pulmonary artery endothelial cells (PAECs). The proinflammatory cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) mediate many of the pathophysiologic effects of endotoxemia and sepsis. Endothelial cells secrete TNF and IL-1 in response to endotoxin. We hypothesize that lipopolysaccharide stimulation of plasma membrane L-arginine transport is mediated via an autocrine cytokine loop involving TNF and IL-1.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0039-6060
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
213-9
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:7846628-Animals,
pubmed-meshheading:7846628-Arginine,
pubmed-meshheading:7846628-Biological Transport,
pubmed-meshheading:7846628-Cells, Cultured,
pubmed-meshheading:7846628-Endothelium, Vascular,
pubmed-meshheading:7846628-Endotoxins,
pubmed-meshheading:7846628-Interleukin-1,
pubmed-meshheading:7846628-Lipopolysaccharides,
pubmed-meshheading:7846628-Pulmonary Artery,
pubmed-meshheading:7846628-Sodium,
pubmed-meshheading:7846628-Swine,
pubmed-meshheading:7846628-Time Factors,
pubmed-meshheading:7846628-Tumor Necrosis Factor-alpha
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pubmed:year |
1995
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pubmed:articleTitle |
Cytokines regulate endotoxin stimulation of endothelial cell arginine transport.
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pubmed:affiliation |
Department of Surgery, University of Florida, Gainesville 32610-0286.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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