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rdf:type |
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lifeskim:mentions |
umls-concept:C0012155,
umls-concept:C0023779,
umls-concept:C0023983,
umls-concept:C0032105,
umls-concept:C0032176,
umls-concept:C0033268,
umls-concept:C0033567,
umls-concept:C0040061,
umls-concept:C0061078,
umls-concept:C0205210,
umls-concept:C0681814,
umls-concept:C1522492
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pubmed:issue |
5
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pubmed:dateCreated |
1995-3-3
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pubmed:abstractText |
Effects of a dietary intake of the polyunsaturated omega-6 essential fatty acids (EFAs) linoleic and gamma-linolenic acids (GLA) on blood lipids, platelet function, and vascular prostacyclin production were studied 12 hyperlipidemic patients (doses of 3 g/day) and 12 male Wistar rats (doses of 3 mg/kg/day) for 4 months. In humans, GLA supplementation decreased plasma triglyceride (TG) levels by 48% (p < 0.001) and increased HDL-cholesterol concentration by 22% (p < 0.01). Total cholesterol and LDL-cholesterol levels were significantly decreased by omega-6 EFAs. Platelet aggregation induced by low concentrations of adenosine diphosphate (ADP) and epinephrine, and serum thromboxane B2 decreased by 45% both in humans and animals after GLA supplementation. Bleeding time increased 40% (p , 0.01). In rats, vascular prostacyclin production measured by radioimmunoassay of 6-keto-PGF1 alpha was enhanced by GLA intake. These effects of omega-6 EFAs may contribute to cardiovascular protection and prevention of the atherosclerotic disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/6-Ketoprostaglandin F1 alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Diphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Epinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Omega-6,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Aggregation Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboxane B2,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Linolenic Acid
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0952-3278
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
311-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7846101-6-Ketoprostaglandin F1 alpha,
pubmed-meshheading:7846101-Adenosine Diphosphate,
pubmed-meshheading:7846101-Animals,
pubmed-meshheading:7846101-Arteriosclerosis,
pubmed-meshheading:7846101-Cholesterol,
pubmed-meshheading:7846101-Cholesterol, HDL,
pubmed-meshheading:7846101-Cholesterol, LDL,
pubmed-meshheading:7846101-Dietary Fats, Unsaturated,
pubmed-meshheading:7846101-Epinephrine,
pubmed-meshheading:7846101-Fatty Acids, Omega-6,
pubmed-meshheading:7846101-Fatty Acids, Unsaturated,
pubmed-meshheading:7846101-Humans,
pubmed-meshheading:7846101-Male,
pubmed-meshheading:7846101-Platelet Aggregation,
pubmed-meshheading:7846101-Platelet Aggregation Inhibitors,
pubmed-meshheading:7846101-Rats,
pubmed-meshheading:7846101-Rats, Wistar,
pubmed-meshheading:7846101-Thromboxane B2,
pubmed-meshheading:7846101-Triglycerides,
pubmed-meshheading:7846101-gamma-Linolenic Acid
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pubmed:year |
1994
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pubmed:articleTitle |
Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production.
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pubmed:affiliation |
Department of Medicine, School of Medicine, University of Chile, Santiago.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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