Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1995-3-6
|
pubmed:abstractText |
The FMS proto-oncogene encodes a polypeptide growth factor receptor expressed on the cell surface of monocytes and B lymphocytes within the haematological system. Mutations of the FMS gene at codons 301 and 969 have been detected in a number of haematological disorders. Mutations at these codons are thought to be important in the pathogenesis of leukaemia in cells expressing a mutant receptor. Following our finding that the colony stimulating factor-1 receptor (CSF-1R) was expressed on B cells, we have assessed DNA from 17 patients with B-cell chronic lymphocytic leukaemia (CLL), 15 with acute lymphoblastic leukaemias (ALL), two samples from patients with B-cell non-Hodgkin's lymphoma (B-NHL), and 20 haematologically normal individuals for the presence of C-terminal mutations of the FMS gene. Using single stranded conformational polymorphism analysis (SSCP), a single band shift was detected resulting from a nucleotide insertion at codon 965 in the DNA isolated from a patient with B-NHL. These results indicate that mutations of the FMS gene in this region are rare in B-cell malignancy but may contribute to the pathogenesis of leukaemias and lymphomas in a small subset of patients. However, the presence of other mutations not detected using this type of analysis cannot be excluded.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0887-6924
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
9
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
155-8
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7845011-Amino Acid Sequence,
pubmed-meshheading:7845011-Base Sequence,
pubmed-meshheading:7845011-Genes, fms,
pubmed-meshheading:7845011-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:7845011-Lymphoma, B-Cell,
pubmed-meshheading:7845011-Molecular Sequence Data,
pubmed-meshheading:7845011-Mutation,
pubmed-meshheading:7845011-Polymerase Chain Reaction,
pubmed-meshheading:7845011-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:7845011-Precursor Cell Lymphoblastic Leukemia-Lymphoma
|
pubmed:year |
1995
|
pubmed:articleTitle |
A C-terminal FMS mutation in a patient with B-cell malignancy.
|
pubmed:affiliation |
Department of Haematology, University of Wales College of Medicine, Cardiff, UK.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|