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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1995-3-9
|
| pubmed:abstractText |
A sensitive and specific polymerase chain reaction method for the detection of human herpesvirus 6 (HHV-6) DNA in serum or plasma has been developed. In total, 157 human serum or plasma samples were studied. HHV-6 DNA was detected in 6 (85.7%) of 7 children with exanthem subitum, 3 (23.1%) of 13 bone marrow transplant (BMT) recipients, 4 (22.2%) of 18 human immunodeficiency virus (HIV)-infected patients, 1 (2.6%) of 39 patients with chronic fatigue syndrome, and none of 37 healthy adults. In the HHV-6-positive BMT recipients, HHV-6 plasma DNA was transiently detected during episodes of fever and respiratory infection. In children with exanthem subitum and in 1 HIV-infected patient, the HHV-6 strains were characterized as variant B, whereas variant A was detected in all other patients. Detection of viral DNA in serum or plasma is a marker of active infection that can be used to investigate the role of HHV-6 in human disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
171
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
273-80
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:7844362-Adult,
pubmed-meshheading:7844362-Base Sequence,
pubmed-meshheading:7844362-Bone Marrow Transplantation,
pubmed-meshheading:7844362-Child,
pubmed-meshheading:7844362-Child, Preschool,
pubmed-meshheading:7844362-DNA, Viral,
pubmed-meshheading:7844362-Exanthema Subitum,
pubmed-meshheading:7844362-Female,
pubmed-meshheading:7844362-Genetic Variation,
pubmed-meshheading:7844362-HIV Infections,
pubmed-meshheading:7844362-Herpesviridae Infections,
pubmed-meshheading:7844362-Herpesvirus 6, Human,
pubmed-meshheading:7844362-Humans,
pubmed-meshheading:7844362-Immunocompromised Host,
pubmed-meshheading:7844362-Male,
pubmed-meshheading:7844362-Middle Aged,
pubmed-meshheading:7844362-Molecular Sequence Data,
pubmed-meshheading:7844362-Polymerase Chain Reaction,
pubmed-meshheading:7844362-Sensitivity and Specificity,
pubmed-meshheading:7844362-Viremia
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction.
|
| pubmed:affiliation |
Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|