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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1995-3-6
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pubmed:abstractText |
During the course of our screening program for natural product drugs effective against multidrug resistant cells by using adriamycin resistant HL-60 cells, we have discovered a new 12 membered macrolide FD-895 in the fermentation broth of Streptomyces hygroscopicus A-9561 isolated from a soil sample collected at Iriomote Island, Okinawa prefecture, Japan. FD-895 showed stronger cytocidal activities against in vitro tumor cell lines than adriamycin. FD-895 had the same IC50 values against parent and adriamycin resistant HL-60 cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1395-401
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7844034-Anti-Bacterial Agents,
pubmed-meshheading:7844034-Antibiotics, Antineoplastic,
pubmed-meshheading:7844034-Drug Screening Assays, Antitumor,
pubmed-meshheading:7844034-Fermentation,
pubmed-meshheading:7844034-HeLa Cells,
pubmed-meshheading:7844034-Humans,
pubmed-meshheading:7844034-Macrolides,
pubmed-meshheading:7844034-Magnetic Resonance Spectroscopy,
pubmed-meshheading:7844034-Mass Spectrometry,
pubmed-meshheading:7844034-Microscopy, Electron, Scanning,
pubmed-meshheading:7844034-Molecular Structure,
pubmed-meshheading:7844034-Streptomyces,
pubmed-meshheading:7844034-Tumor Cells, Cultured
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pubmed:year |
1994
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pubmed:articleTitle |
Isolation and characterization of a new 12-membered macrolide FD-895.
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pubmed:affiliation |
Dept. of Applied Biology, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
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pubmed:publicationType |
Journal Article
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