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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1995-3-3
|
| pubmed:abstractText |
The distribution of complex carbohydrate structures during the embryonic development of the rat palate was analysed by examining lectin-binding patterns in serial paraffin and cryostat sections. With few exceptions, the binding patterns showed a general increase in lectin receptors in the more developed stages of palatogenesis. High mannose oligosaccharides were especially amplified during development. Terminal fucose molecules were not expressed. In contrast, terminal sialic acid molecules were ubiquitously distributed in epithelial and mesenchymal tissues. Non-sialylated terminal N-acetylglucosamine was specifically restricted to evolving bone matrix. Before palatal fusion, quantitative but not qualitative differences were detected between oral, nasal, and medial-edge epithelial surfaces. The only exception was LCA, which specifically marked epithelial cells at the tip of palatal shelves. A very selective affinity for Jacalin was demonstrated in the oral epithelium of the palate after day 16, suggesting the presence of sialylated terminal galactose-(beta-1,3)-N-acetylgalactosamine. PNA specifically marked the basal lamina of the oral side of palatal processes. The binding patterns of DBA, GSL IA, SBA, and VVA indicated that the epithelium of the tongue is characterized by terminal alpha- and beta-galactose residues, whereas palatine cells possess only molecules with beta-anomery. During palatogenesis, glycosaminoglycans patterns were significantly modified. Our data suggest that alteration of complex carbohydrate structures may play a central role in modulating cell-cell and cell-matrix interactions. The significance of these findings, however, remains to be elucidated.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylglucosamine,
http://linkedlifedata.com/resource/pubmed/chemical/Fucose,
http://linkedlifedata.com/resource/pubmed/chemical/Galactose,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Mannose,
http://linkedlifedata.com/resource/pubmed/chemical/Oligosaccharides
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0018-2214
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
705-20
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7843984-Acetylglucosamine,
pubmed-meshheading:7843984-Animals,
pubmed-meshheading:7843984-Carbohydrate Sequence,
pubmed-meshheading:7843984-Extracellular Matrix,
pubmed-meshheading:7843984-Female,
pubmed-meshheading:7843984-Fucose,
pubmed-meshheading:7843984-Galactose,
pubmed-meshheading:7843984-Glucose,
pubmed-meshheading:7843984-Glycoconjugates,
pubmed-meshheading:7843984-Immunohistochemistry,
pubmed-meshheading:7843984-Lectins,
pubmed-meshheading:7843984-Male,
pubmed-meshheading:7843984-Mannose,
pubmed-meshheading:7843984-Molecular Sequence Data,
pubmed-meshheading:7843984-Oligosaccharides,
pubmed-meshheading:7843984-Palate,
pubmed-meshheading:7843984-Paraffin Embedding,
pubmed-meshheading:7843984-Pregnancy,
pubmed-meshheading:7843984-Rats,
pubmed-meshheading:7843984-Rats, Sprague-Dawley,
pubmed-meshheading:7843984-Tissue Distribution
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Distribution patterns in glycoconjugate expression during the development of the rat palate.
|
| pubmed:affiliation |
Institute of Anatomy and Cell Biology, Johannes Gutenberg-University of Mainz, Germany.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|