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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1995-3-8
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pubmed:abstractText |
Both V79 and As/R28A cells (an arsenite-resistant Chinese hamster V79 cell variant) show increased resistance to toxic concentrations of arsenite after pretreatment with a nontoxic concentration. The induced tolerance can be completely inhibited by actinomycin D or cycloheximide. Pretreatment with a nontoxic heat shock (45 degrees C, 10 min) resulted in a clear increased thermotolerance in both cell lines but failed to induce arsenite tolerance in either cell line. Pretreatment with arsenite induced a thermotolerance in V79 cells but not in As/R28A cells. These results are consistent with a model whereby the signal for induction of arsenite tolerance involves binding of arsenite to a protein effector which is amplified in the As/R28A line, thereby preventing action of arsenite in the regulation of heat shock factor which induces the heat shock response.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-1281272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-1332730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-1688427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-1967174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-2179980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-2340977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-3388020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-3392425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-3412774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-3545184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-3597553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-3840060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-3899634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-6459229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-6841458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-7207493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843143-8430428
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0091-6765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
102 Suppl 3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
97-100
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7843143-Animals,
pubmed-meshheading:7843143-Arsenites,
pubmed-meshheading:7843143-Cell Line,
pubmed-meshheading:7843143-Cycloheximide,
pubmed-meshheading:7843143-Dactinomycin,
pubmed-meshheading:7843143-Drug Resistance,
pubmed-meshheading:7843143-Drug Tolerance,
pubmed-meshheading:7843143-Hot Temperature,
pubmed-meshheading:7843143-Protein Biosynthesis,
pubmed-meshheading:7843143-RNA, Messenger,
pubmed-meshheading:7843143-Sodium Compounds
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pubmed:year |
1994
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pubmed:articleTitle |
Induction of arsenite tolerance and thermotolerance by arsenite occur by different mechanisms.
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pubmed:affiliation |
Norton Nelson Institute of Environmental Medicine, New York University Medical Center, New York.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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