Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1995-3-7
|
| pubmed:abstractText |
Effects of 50% ethanolic extract (JR-ext) from Chinese Rehmanniae Radix (the steamed and dried root of Rehmannia glutinosa, "Jyuku-Jio" in Japanese) on the hemorheology of inflammatory, thrombosic and intact animals were examined in the in vivo models. JR-ext (200 mg/kg, p.o.) inhibited the reduction of fibrinolytic activity and erythrocyte deformability, the decrease in erythrocyte counts and the increase in connective tissue of the thoracic artery in a chronic inflammatory model, adjuvant-induced arthritis. However, JR-ext was ineffective on the development of edema in the arthritic rats and on acute and chronic inflammation. JR-ext inhibited the reduction of erythrocyte deformability, but not the decrease of coagulative factors in a thrombosic model, endotoxin-induced disseminated intravascular coagulation (DIC). JR-ext also showed a promoting effect on erythrocyte deformability and fibrinolytic activity in intact rats. These results suggest that orally administered JR-ext can prevent an inducement of impediment in the peripheral microcirculation of various chronic diseases through the improvement of hemorheology.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Carrageenan,
http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Chinese Herbal,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyproline,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0918-6158
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1282-6
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7841954-Acetic Acids,
pubmed-meshheading:7841954-Animals,
pubmed-meshheading:7841954-Arthritis, Experimental,
pubmed-meshheading:7841954-Blood Cell Count,
pubmed-meshheading:7841954-Blood Viscosity,
pubmed-meshheading:7841954-Capillary Permeability,
pubmed-meshheading:7841954-Carrageenan,
pubmed-meshheading:7841954-Drugs, Chinese Herbal,
pubmed-meshheading:7841954-Edema,
pubmed-meshheading:7841954-Erythrocyte Deformability,
pubmed-meshheading:7841954-Female,
pubmed-meshheading:7841954-Granuloma,
pubmed-meshheading:7841954-Hydroxyproline,
pubmed-meshheading:7841954-Male,
pubmed-meshheading:7841954-Mice,
pubmed-meshheading:7841954-Mice, Inbred Strains,
pubmed-meshheading:7841954-Plant Extracts,
pubmed-meshheading:7841954-Rats,
pubmed-meshheading:7841954-Rats, Sprague-Dawley,
pubmed-meshheading:7841954-Rats, Wistar,
pubmed-meshheading:7841954-Thrombosis
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Studies on rehmanniae radix. I. Effect of 50% ethanolic extract from steamed and dried rehmanniae radix on hemorheology in arthritic and thrombosic rats.
|
| pubmed:affiliation |
Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan.
|
| pubmed:publicationType |
Journal Article
|