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pubmed:abstractText |
In an isolated vestibular organ preparation from the axolotl (Ambystoma tigrinum), glycine (10-0.01 microM) perfusion had no effect in the resting control condition, but significantly modified the response of afferent fibres to mechanical stimuli, producing a slowly increasing discharge rate during sinusoidal mechanical stimulation periods. This action was dependent upon the stimulus duration and was antagonized by 7-chloro-kynurenic acid (7-ClKyn), 2-amino-5-phosphonopentanoic acid (AP5), N-allyl-nor-metazocina (MK-801) and extracellular magnesium. These results indicate that glycine modulates the afferent synapse in the vestibular organ, and that, NMDA receptors codify long lasting mechanical stimuli.
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