Linked Life Data

7841147

Source:http://linkedlifedata.com/resource/pubmed/id/7841147

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-3-8
pubmed:abstractText
Three polymers, produced as reference materials of a European Communities program, namely PE, PP, and PVC, in tubular form, were comparatively evaluated for their hemocompatibility. In particular, the following parameters: platelet retention index, beta-thromboglobulin (beta-TG) release from activated platelets, and expression of the platelet protein GMP 140 (PADGEM) were measured as a function of time for whole anticoagulated human blood flowing in a closed-loop system under two different shear rates of 2000 and 500 s-1. Data up to 20 min (afterwards there was hemolysis) showed a fluctuating platelet retention index as time increased for PE and PVC and an increasing value for PP. Platelet aggregation and dislodgment from the surface could not be differentiated. Activation of platelets as expressed with beta-TG release were higher for both PE and PP in both shear rates in comparison to PVC which elicited a higher response at the high shear rate. Finally, PADGEM estimations seem to indicate a more stable platelet retention layer for PP than PE or PVC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0920-5063
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
399-410
pubmed:dateRevised
2008-2-20
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
The effect of shear rate on the adhesion/activation of human platelets in flow through a closed-loop polymeric tubular system.
pubmed:affiliation
Department of Mechanical Engineering, University of Patras, Greece.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't