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rdf:type |
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lifeskim:mentions |
umls-concept:C0006142,
umls-concept:C0010709,
umls-concept:C0019929,
umls-concept:C0033308,
umls-concept:C0033684,
umls-concept:C0039286,
umls-concept:C0087111,
umls-concept:C0683956,
umls-concept:C1167622,
umls-concept:C1280500,
umls-concept:C1446409,
umls-concept:C1522673
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pubmed:issue |
5B
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pubmed:dateCreated |
1995-3-2
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pubmed:abstractText |
Progesterone binding cyst protein (PBCP) was measured in breast cancer cytosols from 128 pre- and post-menopausal women with operable node positive (pN+) breast cancer Stage II. All patients were included in a national multicenter study on the effect of adjuvant tamoxifen treatment in hormone sensitive breast cancer, i.e. estrogen receptor content of at least 10 pmol/g cytosol protein. Patients were randomised to receive adjuvant tamoxifen 20 mg once daily for two years or no endocrine treatment. At a median follow-up of 60 months, we found PBCP content in the primary tumor to be an important factor with regard to the effect of adjuvant tamoxifen treatment. The benefit of adjuvant tamoxifen treatment on relapse-free survival and overall survival was confined to the subpopulation of patients with PBCP negative tumors. PBCP should be further evaluated as a predictive factor for the effect of tamoxifen treatment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/APOD protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins D,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Tamoxifen,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2105-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7840507-Adult,
pubmed-meshheading:7840507-Aged,
pubmed-meshheading:7840507-Apolipoproteins,
pubmed-meshheading:7840507-Apolipoproteins D,
pubmed-meshheading:7840507-Breast Neoplasms,
pubmed-meshheading:7840507-Carrier Proteins,
pubmed-meshheading:7840507-Chemotherapy, Adjuvant,
pubmed-meshheading:7840507-Disease-Free Survival,
pubmed-meshheading:7840507-Female,
pubmed-meshheading:7840507-Glycoproteins,
pubmed-meshheading:7840507-Humans,
pubmed-meshheading:7840507-Membrane Transport Proteins,
pubmed-meshheading:7840507-Middle Aged,
pubmed-meshheading:7840507-Neoplasm Proteins,
pubmed-meshheading:7840507-Prognosis,
pubmed-meshheading:7840507-Receptors, Estrogen,
pubmed-meshheading:7840507-Receptors, Progesterone,
pubmed-meshheading:7840507-Retrospective Studies,
pubmed-meshheading:7840507-Survival Rate,
pubmed-meshheading:7840507-Tamoxifen,
pubmed-meshheading:7840507-Tumor Markers, Biological
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pubmed:articleTitle |
Progesterone binding cyst protein in hormone receptor positive breast cancer; a predictive factor for effect of adjuvant tamoxifen treatment.
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pubmed:affiliation |
Department of Surgery, Rogaland Central Hospital, Stavanger, Norway.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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