Linked Life Data

7839698

Source:http://linkedlifedata.com/resource/pubmed/id/7839698

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1995-2-27
pubmed:abstractText
1. The toxicokinetics and biotransformation of pentachlorophenol (PCP) were determined in the purple sea urchin (Strongylocentrotus purpuratus). 2. In a static chamber, urchins (n = 9) were individually exposed to 50 micrograms/l of [U-14C]PCP for 24 h to determine bioconcentration and the absorption rate constant (Ka), elimination rate constant (Ke), and elimination half-life (t1/2). Determination was by direct quantitation of radioactivity in the exposure water. 3. After exposure, urchins were placed in a flow-through chamber for 24 h to allow depuration of retained residues, which were identified by hplc and quantified by lsc. The Ka and Ke, calculated using a simplified model, were 0.12 +/- 0.06 h and 0.43 +/- 0.22 h, respectively, whilst the 24-h total concentration factor was 316.3 +/- 209.7, and the t1/2 was 1.6 +/- 0.8 h. 4. Whereas urchins depurated 40.6% of retained residues, only a small amount of PCP was excreted unchanged (17.0%), as the more polar conjugates pentachlorophenyl-beta-D-glucoside (72.4%) and pentachlorophenylsulphate (10.6%) were also formed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0049-8254
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
749-57
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Toxicokinetics and biotransformation of pentachlorophenol in the sea urchin (Strongylocentrotus purpuratus).
pubmed:affiliation
Department of Chemistry and Biochemistry, University of California, Santa Cruz 95064.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't