Linked Life Data

7839448

Source:http://linkedlifedata.com/resource/pubmed/id/7839448

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-3-2
pubmed:abstractText
Infusion of donor bone marrow cells (DBMC), a long-standing, successful strategy for inducing tolerance in experimental rodent transplantation models, can promote long-term acceptance of life-sustaining renal allografts in rhesus monkeys with no maintenance immunosuppression. To investigate the immunological basis for heterogeneity in duration of long-term graft acceptance following infusion of the DR-/dim fraction of DBMC into RATG-treated rhesus monkeys, we examined the relationship of recipient-donor major histo-compatibility class I and II DR matching to the development of antidonor antibody-dependent cellular cytotoxicity (ADCC) and renal allograft survival. The findings indicate a requirement for sharing one DR allele to achieve long-term graft acceptance. The observed immunological consequence of DR sharing that correlated with functional graft tolerance in this model was the suppression of early antidonor ADCC+ IgG antibody responses. Significant associations were observed between graft survival and suppression of ADCC antibody (P < 0.0005), graft survival and DR sharing (P < 0.005), and DR sharing and suppression of ADCC (P < 0.02). Early antidonor ADCC antibody responses associated with failure to maintain graft tolerance and were most consistently directed to donor class I. The required one DR antigen sharing in DBMC-induced suppression of antidonor class I antibody suggests a restriction for recipient DR, implying critical regulation of a response to donor antigen presented on recipient cells. We hypothesize a DBMC tolerogenic mechanism in which presentation of donor class I peptide by a shared DR allele configuration allows a veto effect by DBMC. Thus DR sharing would allow DBMC veto cells to reduce clonal expansion elicited by both the direct and indirect antigen presentation pathways.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0041-1337
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-55
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:7839448-Animals, pubmed-meshheading:7839448-Antibody-Dependent Cell Cytotoxicity, pubmed-meshheading:7839448-Base Sequence, pubmed-meshheading:7839448-Bone Marrow Transplantation, pubmed-meshheading:7839448-Graft Rejection, pubmed-meshheading:7839448-Graft Survival, pubmed-meshheading:7839448-HLA-DR Antigens, pubmed-meshheading:7839448-Histocompatibility Antigens Class I, pubmed-meshheading:7839448-Histocompatibility Antigens Class II, pubmed-meshheading:7839448-Immune Tolerance, pubmed-meshheading:7839448-Immunoglobulin G, pubmed-meshheading:7839448-Kidney Transplantation, pubmed-meshheading:7839448-Macaca mulatta, pubmed-meshheading:7839448-Male, pubmed-meshheading:7839448-Molecular Sequence Data, pubmed-meshheading:7839448-Rabbits, pubmed-meshheading:7839448-Tissue Donors
pubmed:year
1995
pubmed:articleTitle
The facilitating effect of one-DR antigen sharing in renal allograft tolerance induced by donor bone marrow in rhesus monkeys.
pubmed:affiliation
Department of Surgery, University Medical Center of Eastern North Carolina, Greenville 27834.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.