rdf:type |
|
lifeskim:mentions |
umls-concept:C0001002,
umls-concept:C0010763,
umls-concept:C0017262,
umls-concept:C0026809,
umls-concept:C0035696,
umls-concept:C0162788,
umls-concept:C0185117,
umls-concept:C0205054,
umls-concept:C0936012,
umls-concept:C1709059,
umls-concept:C2911684
|
pubmed:issue |
1
|
pubmed:dateCreated |
1995-2-24
|
pubmed:abstractText |
Cytochrome P450 2E1 is a distinct enzyme induced by diverse agents and notably by solvents including acetone. The P450 2E1 apoprotein is predominantly localized in the centrilobular region of the hepatic lobule in the constitutive state and after induction with acetone. In this study, we investigated the level and pattern of distribution of the 2E1 mRNA within the hepatic lobule in control mice and in mice exposed to acetone under acute and chronic conditions.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0023-6837
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
72
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
92-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7837796-Acetone,
pubmed-meshheading:7837796-Animals,
pubmed-meshheading:7837796-Cytochrome P-450 CYP2E1,
pubmed-meshheading:7837796-Cytochrome P-450 Enzyme System,
pubmed-meshheading:7837796-Image Processing, Computer-Assisted,
pubmed-meshheading:7837796-In Situ Hybridization,
pubmed-meshheading:7837796-Liver,
pubmed-meshheading:7837796-Male,
pubmed-meshheading:7837796-Mice,
pubmed-meshheading:7837796-Mice, Inbred Strains,
pubmed-meshheading:7837796-Oxidoreductases, N-Demethylating,
pubmed-meshheading:7837796-RNA, Messenger
|
pubmed:year |
1995
|
pubmed:articleTitle |
In situ hybridization analysis of hepatic cytochrome P450 2E1 messenger ribonucleic acid in mice. Modulation of expression by acetone.
|
pubmed:affiliation |
Department of Anatomy and Cell Biology, Queen's University, Kingston, Ontario, Canada.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|