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rdf:type |
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lifeskim:mentions |
umls-concept:C0005149,
umls-concept:C0026809,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0086418,
umls-concept:C0282641,
umls-concept:C0442805,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2347644,
umls-concept:C2698600
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pubmed:issue |
2
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pubmed:dateCreated |
1995-2-24
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pubmed:abstractText |
Mice harboring a deletion of the gene encoding the transporter associated with antigen presentation-1 (TAP1) are impaired in providing major histocompatibility complex (MHC) class I molecules with peptides of cytosolic origin and lack stable MHC class I cell surface expression. They consequently have a strongly reduced number of CD8+ T cells. To examine whether selection of CD8+ T cells is dependent on TAP-dependent peptides, we partially restored MHC class I cell surface expression in TAP1-deficient mice by introduction of human beta 2-microglobulin. We show that selection of functional CD8+ T cells can be augmented in vivo in the absence of TAP1-dependent peptides.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-1473153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-15335738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-1557127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-1708852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-1848698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-2196996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-2198471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-2199065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-2731965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-3087921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-8022816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-8124708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-8245467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-8287475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-8293460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-8294874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-8376783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-8384560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-8464897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-8476568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-8478616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836931-8500174
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
181
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
787-92
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7836931-ATP-Binding Cassette Transporters,
pubmed-meshheading:7836931-Amino Acid Sequence,
pubmed-meshheading:7836931-Animals,
pubmed-meshheading:7836931-Antigens,
pubmed-meshheading:7836931-Cell Differentiation,
pubmed-meshheading:7836931-Humans,
pubmed-meshheading:7836931-Mice,
pubmed-meshheading:7836931-Mice, Transgenic,
pubmed-meshheading:7836931-Molecular Sequence Data,
pubmed-meshheading:7836931-T-Lymphocytes, Regulatory,
pubmed-meshheading:7836931-beta 2-Microglobulin
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pubmed:year |
1995
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pubmed:articleTitle |
Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene.
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pubmed:affiliation |
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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