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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1995-2-27
|
| pubmed:abstractText |
DDD/1 (DDD) mice contrast strikingly with DDD-mtv-2/mtv-2 (DDD-mtv-2) congenics in their marked lymph node (LN) T cell paucity. To clarify the possible difference in LN function between them, reciprocal LN grafting experiments were conducted. DDD-mtv-2 LN grafts in DDD recipients underwent hyperplasia as dramatic as 10-to 20-fold increase in weight between 3 and 4 wk after implantation. Lymphoid cells in hyperplastic LN grafts were of recipient origin. Similar hyperplasia of mtv-2-heterozygous LN grafts also occurred on various hybrid backgrounds involving DDD mice. Moreover, LN grafts from BALB/c mice infected with mtv-2-derived exogenous mouse mammary tumor virus (MMTV) swelled in MMTV-free BALB/c recipients. Genetic analysis of DDD x (DDD x DDD-mtv-2)F1 backcross progeny demonstrated that LN hyperplasia was closely linked to mtv-2. The frequencies of V beta 5+ and V beta 8+ T cells unresponsive to mtv-2-encoded superantigen (SAg) changed with practically the same kinetics in both LN grafts and recipients' LN. Thus, the cells responsible for LN hyperplasia were polyclonal. V beta 14+ CD4+ cells responsive to mtv-2 SAg were specifically stimulated in recipients' LN but selectively deleted in hyperplastic LN grafts. DDD mice carrying hyperplastic mtv-2+ LN grafts or pretreated with mtv-2+ spleen cells developed an unresponsive state in terms of influx of mtv-2- lymphoid cells into mtv-2+ LN grafts. These results indicate that mtv-2 gene products including SAg may stimulate mtv-2- lymphoid cells of recipients and cause them to migrate into mtv-2+ LN grafts in a nonspecific manner with resulting LN hyperplasia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
154
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1644-52
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7836749-Animals,
pubmed-meshheading:7836749-Antigens, Viral,
pubmed-meshheading:7836749-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7836749-Crosses, Genetic,
pubmed-meshheading:7836749-Female,
pubmed-meshheading:7836749-Graft Survival,
pubmed-meshheading:7836749-Hyperplasia,
pubmed-meshheading:7836749-Lymph Nodes,
pubmed-meshheading:7836749-Male,
pubmed-meshheading:7836749-Mammary Tumor Virus, Mouse,
pubmed-meshheading:7836749-Mice,
pubmed-meshheading:7836749-Mice, Inbred Strains,
pubmed-meshheading:7836749-Models, Immunological,
pubmed-meshheading:7836749-Organ Size,
pubmed-meshheading:7836749-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:7836749-Spleen,
pubmed-meshheading:7836749-Superantigens,
pubmed-meshheading:7836749-T-Lymphocytes
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Dramatic hyperplasia of mtv-2+ lymph node grafts in mtv-2- recipients and selective stimulation of V beta 14+ T cells in recipients' lymph nodes in the DDD mouse.
|
| pubmed:affiliation |
Laboratory Animal Research Center, University of Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|