| pubmed-article:7835926 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7835926 | lifeskim:mentions | umls-concept:C0009325 | lld:lifeskim |
| pubmed-article:7835926 | lifeskim:mentions | umls-concept:C0242629 | lld:lifeskim |
| pubmed-article:7835926 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:7835926 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:7835926 | lifeskim:mentions | umls-concept:C0450363 | lld:lifeskim |
| pubmed-article:7835926 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7835926 | pubmed:dateCreated | 1995-3-1 | lld:pubmed |
| pubmed-article:7835926 | pubmed:abstractText | The spontaneous locomotion of immunomagnetically isolated resting CD4+ and CD8+ lymphocytes in three-dimensional collagen gels was recorded by time-lapse videomicroscopy. Two-dimensional projections of the paths of randomly selected individual cells were digitized, plotted and quantitatively analysed. Among five different donors 46 +/- 10% of CD4+ and CD8+ lymphocytes (n = 180) showed initial spontaneous locomotion (individual speed 5-25 microns/min; mean speed CD4+ 5.2 +/- 3.6 microns, CD8+ 3.23 +/- 2.72 microns). Active CD4+ cells were constantly migrating for more than 4 hr, whereas CD8+ lymphocytes significantly slowed down after 60-90 min in the collagen gel (P < 0.003). Quantitative analysis of the paths indicated at least three migratory phenotypes: (1) spontaneously locomoting cells exhibiting high speed and low frequency of stopping; (2) a major non-motile fraction without significant displacement; and (3) a subpopulation within CD4+ and CD8+ cells with intermediate activity of speed and stopping. Further subtype analysis of immunomagnetically isolated CD45RAhigh/ROlow or CD45RAlow/ROhigh lymphocytes showed that more than 90% of CD4+ CD45RAhigh/ROlow cells were actively locomoting. In contrast, only 20% of the CD4+ CD45ROhigh/RAlow phenotype showed spontaneous motility to a limited degree. The data indicate that resting CD4+ and CD8+ lymphocytes comprise further locomotory subpopulation related to the expression of different CD45 isoforms. | lld:pubmed |
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| pubmed-article:7835926 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7835926 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835926 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7835926 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7835926 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7835926 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:7835926 | pubmed:author | pubmed-author:FriedlPP | lld:pubmed |
| pubmed-article:7835926 | pubmed:author | pubmed-author:ShieldsE DED | lld:pubmed |
| pubmed-article:7835926 | pubmed:author | pubmed-author:NobleP BPB | lld:pubmed |
| pubmed-article:7835926 | pubmed:author | pubmed-author:ZänkerK SKS | lld:pubmed |
| pubmed-article:7835926 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7835926 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:7835926 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7835926 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7835926 | pubmed:pagination | 617-24 | lld:pubmed |
| pubmed-article:7835926 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7835926 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7835926 | pubmed:articleTitle | Locomotor phenotypes of unstimulated CD45RAhigh and CD45ROhigh CD4+ and CD8+ lymphocytes in three-dimensional collagen lattices. | lld:pubmed |
| pubmed-article:7835926 | pubmed:affiliation | Faculty of Dentistry, McGill University, Montreal, Quebec, Canada. | lld:pubmed |
| pubmed-article:7835926 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7835926 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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