| pubmed-article:7835309 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7835309 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7835309 | lifeskim:mentions | umls-concept:C0040132 | lld:lifeskim |
| pubmed-article:7835309 | lifeskim:mentions | umls-concept:C0040160 | lld:lifeskim |
| pubmed-article:7835309 | lifeskim:mentions | umls-concept:C0380603 | lld:lifeskim |
| pubmed-article:7835309 | lifeskim:mentions | umls-concept:C2917322 | lld:lifeskim |
| pubmed-article:7835309 | lifeskim:mentions | umls-concept:C0300926 | lld:lifeskim |
| pubmed-article:7835309 | lifeskim:mentions | umls-concept:C1509144 | lld:lifeskim |
| pubmed-article:7835309 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:7835309 | lifeskim:mentions | umls-concept:C0392337 | lld:lifeskim |
| pubmed-article:7835309 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:7835309 | lifeskim:mentions | umls-concept:C0337051 | lld:lifeskim |
| pubmed-article:7835309 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7835309 | pubmed:dateCreated | 1995-3-2 | lld:pubmed |
| pubmed-article:7835309 | pubmed:abstractText | TSH-induced intracellular Ca2+ concentration ([Ca2+]i) changes in single FRTL-5 thyroid cells were analyzed by digital video imaging of fura-2-loaded cells. More than 80% of the cells responded to as little as 30 nM TSH, resulting in a [Ca2+]i rise in the presence and absence of extracellular Ca2+. One micromolar concentration of N6-(L-2-phenylisopropyl)adenosine (PIA) caused no appreciable [Ca2+]i increase in more than 300 cells examined, but induced the [Ca2+]i elevation in more than 90% of the cells that had previously been treated with TSH. Pertussis toxin treatment abolished the PIA, but not the TSH, action, whereas thapsigargin-induced Ca2+ depletion of the inositol 1,4,5-trisphosphate-sensitive pool inhibited the actions of both TSH and PIA. The time courses of Ca2+ response considerably differentiated among single cells, but showed similarity among different areas in each cell. These results suggest that PIA induces Ca2+ release from the same thapsigargin-sensitive pool as that targeted by TSH. The lack of PIA stimulation of basic fibroblast growth factor-induced phospholipase-C gamma activation as well as the rise in [Ca2+]i suggests that the cooperative PIA action occurs specifically on phospholipase-C beta. | lld:pubmed |
| pubmed-article:7835309 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7835309 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835309 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7835309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835309 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7835309 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:7835309 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:7835309 | pubmed:author | pubmed-author:KondoYY | lld:pubmed |
| pubmed-article:7835309 | pubmed:author | pubmed-author:OkajimaFF | lld:pubmed |
| pubmed-article:7835309 | pubmed:author | pubmed-author:ShoKK | lld:pubmed |
| pubmed-article:7835309 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7835309 | pubmed:volume | 136 | lld:pubmed |
| pubmed-article:7835309 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7835309 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7835309 | pubmed:pagination | 770-8 | lld:pubmed |
| pubmed-article:7835309 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:7835309 | pubmed:meshHeading | pubmed-meshheading:7835309-... | lld:pubmed |
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| pubmed-article:7835309 | pubmed:meshHeading | pubmed-meshheading:7835309-... | lld:pubmed |
| pubmed-article:7835309 | pubmed:meshHeading | pubmed-meshheading:7835309-... | lld:pubmed |
| pubmed-article:7835309 | pubmed:meshHeading | pubmed-meshheading:7835309-... | lld:pubmed |
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| pubmed-article:7835309 | pubmed:meshHeading | pubmed-meshheading:7835309-... | lld:pubmed |
| pubmed-article:7835309 | pubmed:meshHeading | pubmed-meshheading:7835309-... | lld:pubmed |
| pubmed-article:7835309 | pubmed:meshHeading | pubmed-meshheading:7835309-... | lld:pubmed |
| pubmed-article:7835309 | pubmed:meshHeading | pubmed-meshheading:7835309-... | lld:pubmed |
| pubmed-article:7835309 | pubmed:meshHeading | pubmed-meshheading:7835309-... | lld:pubmed |
| pubmed-article:7835309 | pubmed:meshHeading | pubmed-meshheading:7835309-... | lld:pubmed |
| pubmed-article:7835309 | pubmed:meshHeading | pubmed-meshheading:7835309-... | lld:pubmed |
| pubmed-article:7835309 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7835309 | pubmed:articleTitle | Cooperation of thyrotropin, but not basic fibroblast growth factor, with an adenosine receptor agonist in Ca2+ mobilization from thapsigargin-sensitive pools in single FRTL-5 thyroid cells. | lld:pubmed |
| pubmed-article:7835309 | pubmed:affiliation | Laboratory of Signal Transduction, Gunma University, Maebashi, Japan. | lld:pubmed |
| pubmed-article:7835309 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7835309 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
