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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
6
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|
pubmed:dateCreated |
1995-2-28
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|
pubmed:abstractText |
We investigated the potential value of 50:50 poly (DL glycolic acid-lactic acid) (PGLA) copolymer as a degradable depot delivery system for 5-fluorouracil (5-FU) after filtration surgery. Analysis of retrieved discs after implantation in 22 eyes of 22 pigmented rabbits showed a dual drug release profile and polymer mass loss characteristics. In a second group of pigmented rabbits implantation of PGLA discs impregnated with 5-FU (22 eyes) significantly lengthened the survival time of filtration fistulae compared with discs without 5-FU (18 eyes) or no disc (10 eyes) (p < 0.0001). Use of PGLA copolymer impregnated with 5-FU could prove valuable for patients undergoing glaucoma filtering surgery.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Dec
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|
pubmed:issn |
0008-4182
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
263-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7834564-Animals,
pubmed-meshheading:7834564-Biocompatible Materials,
pubmed-meshheading:7834564-Biodegradation, Environmental,
pubmed-meshheading:7834564-Conjunctiva,
pubmed-meshheading:7834564-Drug Delivery Systems,
pubmed-meshheading:7834564-Filtering Surgery,
pubmed-meshheading:7834564-Fluorouracil,
pubmed-meshheading:7834564-Glaucoma,
pubmed-meshheading:7834564-Glycolates,
pubmed-meshheading:7834564-Lactates,
pubmed-meshheading:7834564-Lactic Acid,
pubmed-meshheading:7834564-Polymers,
pubmed-meshheading:7834564-Rabbits,
pubmed-meshheading:7834564-Random Allocation
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pubmed:year |
1994
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|
pubmed:articleTitle |
Depot drug delivery system for 5-fluorouracil after filtration surgery in the rabbit.
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pubmed:affiliation |
Department of Ophthalmology, University of Toronto, ON.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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