Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-3-1
pubmed:abstractText
1. In pentobarbitone anaesthetized dogs, preganglionic stimulation of the superior cervical sympathetic nerve (15V, 1 ms, 10 Hz) induced marked reduction of nasal arterial blood flow, whereas parasympathetic nerve stimulation (5 V, 1 ms, 10-30 Hz) evoked frequency-dependent vasodilatation. 2. Sympathetic nerve stimulation for 3 min at 10 Hz evoked significant (P < 0.05) and prolonged attenuation of the vasodilator response to subsequent parasympathetic stimulation. Pretreatment with phentolamine (0.5 mg kg-1 h-1), propranolol (1 mg kg-1) and atropine (0.5 mg kg-1) reduced the vasoconstrictor effect of sympathetic stimulation by 35 +/- 4% whereas the parasympathetic nerve-evoked vasodilatation was not significantly modified. Atropine-resistant parasympathetic vasodilatation remained significantly attenuated for more than 30 min after non-adrenergic sympathetic nerve-evoked vasoconstriction. 3. Vasodilator effects of exogenous vasoactive intestinal polypeptide and peptide histidine isoleucine and vasoconstrictor effects of exogenous neuropeptide Y (NPY) and the NPY analogue [Leu31, Pro34] NPY (Y1-receptor agonist, 8 nmol kg-1), were not altered by adrenoceptor antagonists and atropine f1p4eas the effects of exogenous noradrenaline and acetylcholine were virtually abolished. Attenuation of parasympathetic-evoked vasodilatation could be mimicked by exogenous NPY (8 nmol kg-1) and the NPY analogue, N-acetyl [Leu28, Leu31] NPY 24-36 (Y2-receptor agonist, 20 nmol kg-1) but not by exogenous Y1-receptor agonist. The Y2-receptor agonist did not show significant vasoconstrictor action. 4. It is concluded that sympathetic nerve stimulation attenuates parasympathetic vasodilatation via NPY release acting on prejunctional Y2 receptors.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-1321422, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-1712845, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-2153286, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-2170253, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-2196862, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-2297779, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-2568728, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-2832184, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-2859560, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-2873858, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-2898787, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-3010387, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-3223306, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-362800, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-4146975, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-4432746, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-4702425, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-4829047, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-4854660, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-6382200, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-6548019, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-665214, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-6763452, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-6946470, http://linkedlifedata.com/resource/pubmed/commentcorrection/7834199-7468189
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
113
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
479-84
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Modulation by neuropeptide Y of parasympathetic nerve-evoked nasal vasodilatation via Y2 prejunctional receptor.
pubmed:affiliation
Prince of Wales Medical Research Institute, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't