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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-2-27
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pubmed:databankReference |
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pubmed:abstractText |
We have cloned and mapped the chromosomal location of three novel human genes encoding G protein-coupled receptors that we have named GPR6, GPR5, and GPR4. The entire coding region for each of these genes was contained on single exons. Gene GPR6 encoded a receptor that shared closest identity (71% in the transmembrane regions) with the human orphan receptor GPR3 and was localized to chromosome 6 (q21-q22.1). Northern blot analysis revealed that GPR6 transcripts were abundant in the human putamen and to a lesser extent in the frontal cortex, hippocampus, and hypothalamus. Gene GPR5 encoded a receptor that most closely resembled the orphan receptor RBS11 (48% in the transmembrane regions) and the MIP 1 alpha/RANTES receptor (45% in the transmembrane regions) and was localized to chromosome 3 (p21.3-p21.1). Gene GPR4 shared identity (40% in the transmembrane regions) with the human platelet-activating factor receptor and was localized to chromosome 19 (q13.2-q13.3).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Somatostatin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1044-5498
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
25-35
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pubmed:dateRevised |
2008-5-6
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pubmed:meshHeading |
pubmed-meshheading:7832990-Amino Acid Sequence,
pubmed-meshheading:7832990-Animals,
pubmed-meshheading:7832990-Base Sequence,
pubmed-meshheading:7832990-Brain Chemistry,
pubmed-meshheading:7832990-Chromosome Mapping,
pubmed-meshheading:7832990-Cloning, Molecular,
pubmed-meshheading:7832990-Exons,
pubmed-meshheading:7832990-Genes,
pubmed-meshheading:7832990-Humans,
pubmed-meshheading:7832990-Membrane Proteins,
pubmed-meshheading:7832990-Molecular Sequence Data,
pubmed-meshheading:7832990-Polymerase Chain Reaction,
pubmed-meshheading:7832990-RNA, Messenger,
pubmed-meshheading:7832990-Rats,
pubmed-meshheading:7832990-Receptors, Cell Surface,
pubmed-meshheading:7832990-Receptors, G-Protein-Coupled,
pubmed-meshheading:7832990-Receptors, Opioid,
pubmed-meshheading:7832990-Receptors, Somatostatin,
pubmed-meshheading:7832990-Sequence Alignment,
pubmed-meshheading:7832990-Sequence Analysis, DNA,
pubmed-meshheading:7832990-Sequence Homology, Amino Acid
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pubmed:year |
1995
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pubmed:articleTitle |
Isolation of three novel human genes encoding G protein-coupled receptors.
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pubmed:affiliation |
Department of Pharmacology, University of Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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