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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-2-22
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pubmed:databankReference |
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pubmed:abstractText |
We have isolated chicken cDNA clones of the c-qin gene, the cellular counterpart of the v-qin (Chinese for "avian") oncogene of avian sarcoma virus 31. There are several differences between the cellular and the viral qin sequences: (i) two nonconservative amino acid substitutions in the Qin coding region; (ii) a truncation in the carboxyl terminus of the viral protein due to a premature stop codon; (iii) a partial Gag sequence fused to the amino terminus of viral Qin; and (iv) eight cell-coded amino acids which link the cellular Qin coding domain to the viral Gag domain. We have also characterized the expression pattern of c-qin in chicken embryos by in situ hybridization and by Northern blot analysis. c-qin is abundantly expressed in the developing brain, and this expression is restricted to the telencephalon of early embryos.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-1317319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-1324404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-1350202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-1499231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-1559610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-1672118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-2174572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-2192357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-2225060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-2227418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-2243767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-2566386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-2786140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-3943125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-8099441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-8248124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-8265594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-8332212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7831308-8424466
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
447-51
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pubmed:dateRevised |
2011-6-6
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pubmed:meshHeading |
pubmed-meshheading:7831308-Amino Acid Sequence,
pubmed-meshheading:7831308-Animals,
pubmed-meshheading:7831308-Avian Proteins,
pubmed-meshheading:7831308-Base Sequence,
pubmed-meshheading:7831308-Blotting, Northern,
pubmed-meshheading:7831308-Blotting, Southern,
pubmed-meshheading:7831308-Chick Embryo,
pubmed-meshheading:7831308-Chickens,
pubmed-meshheading:7831308-Cloning, Molecular,
pubmed-meshheading:7831308-DNA, Complementary,
pubmed-meshheading:7831308-DNA Probes,
pubmed-meshheading:7831308-Forkhead Transcription Factors,
pubmed-meshheading:7831308-Gene Dosage,
pubmed-meshheading:7831308-In Situ Hybridization,
pubmed-meshheading:7831308-Molecular Sequence Data,
pubmed-meshheading:7831308-Oncogene Proteins,
pubmed-meshheading:7831308-Oncogenes,
pubmed-meshheading:7831308-Proto-Oncogene Proteins,
pubmed-meshheading:7831308-RNA, Messenger,
pubmed-meshheading:7831308-Sequence Analysis, DNA,
pubmed-meshheading:7831308-Sequence Homology, Amino Acid,
pubmed-meshheading:7831308-Telencephalon,
pubmed-meshheading:7831308-Tissue Distribution,
pubmed-meshheading:7831308-Viral Proteins
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pubmed:year |
1995
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pubmed:articleTitle |
Avian cellular homolog of the qin oncogene.
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pubmed:affiliation |
Scripps Research Institute, La Jolla, CA 92037.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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