Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6512
pubmed:dateCreated
1995-2-17
pubmed:abstractText
T lymphocytes of the alpha/beta T-cell receptor (TCR) lineage mature in the thymus, where they undergo a series of differentiation, expansion and selection events. For normal T-cell ontogeny to occur, thymocytes must interact physically with cortical and medullary thymic stroma cells. In parallel, interactions of the thymic stromal cells with TCR-positive thymocytes are necessary for the development of the thymic medulla. Comparable requirements for the differentiation of the cortex have not been defined, however. Here we analyse mutant mouse strains to assess the function of early prothymocytes in the induction of the thymic cortex. We find that animals with a developmental block at the earliest stage of T-lineage commitment lack a functional thymic cortex. This abnormality could be corrected in fetal but not adult animals by transplantation of either fetal or adult wild-type haematopoietic stem cells. Thus a developmentally restricted interaction of fetal stromal cells with early prothymocytes is required for the induction of a cortical microenvironment. In addition, a normal thymic architecture is necessary for sustained T-cell ontogeny.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
373
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
350-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7830770-Aging, pubmed-meshheading:7830770-Animals, pubmed-meshheading:7830770-Antigens, CD, pubmed-meshheading:7830770-Antigens, CD3, pubmed-meshheading:7830770-Bone Marrow Cells, pubmed-meshheading:7830770-DNA-Binding Proteins, pubmed-meshheading:7830770-Embryonic Induction, pubmed-meshheading:7830770-Hematopoiesis, Extramedullary, pubmed-meshheading:7830770-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:7830770-Humans, pubmed-meshheading:7830770-Immunophenotyping, pubmed-meshheading:7830770-Mice, pubmed-meshheading:7830770-Mice, Inbred C57BL, pubmed-meshheading:7830770-Mice, Inbred CBA, pubmed-meshheading:7830770-Mice, Mutant Strains, pubmed-meshheading:7830770-Mice, Transgenic, pubmed-meshheading:7830770-Nuclear Proteins, pubmed-meshheading:7830770-Proteins, pubmed-meshheading:7830770-T-Lymphocytes, pubmed-meshheading:7830770-Thymus Gland
pubmed:year
1995
pubmed:articleTitle
Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes.
pubmed:affiliation
Division of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't