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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-2-17
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pubmed:abstractText |
The human beta-catenin locus (CTNNB1) was mapped by in situ fluorescence analysis to band p21 on the short arm of chromosome 3, a region frequently affected by somatic alterations in a variety of tumors. PCR primers for the genomic amplification of beta-catenin sequences were selected on the basis of homology to exon 4 of the Drosophila armadillo gene. Analysis of a panel of somatic cell hybrids confirmed the localization of beta-catenin on human chromosome 3. Furthermore, exclusion mapping of three hybrids carrying defined fragments of the short arm of human chromosome 3 allowed us to determine the position of the CTNNB1 locus close to the marker D3S2 in 3p21.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenomatous Polyposis Coli Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Armadillo Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/armadillo protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
23
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pubmed:geneSymbol |
CTNNB1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
272-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7829088-Adenomatous Polyposis Coli Protein,
pubmed-meshheading:7829088-Animals,
pubmed-meshheading:7829088-Armadillo Domain Proteins,
pubmed-meshheading:7829088-Base Sequence,
pubmed-meshheading:7829088-Chromosome Mapping,
pubmed-meshheading:7829088-Chromosomes, Human, Pair 3,
pubmed-meshheading:7829088-Cytoskeletal Proteins,
pubmed-meshheading:7829088-Drosophila Proteins,
pubmed-meshheading:7829088-Drosophila melanogaster,
pubmed-meshheading:7829088-Genes,
pubmed-meshheading:7829088-Humans,
pubmed-meshheading:7829088-Hybrid Cells,
pubmed-meshheading:7829088-In Situ Hybridization, Fluorescence,
pubmed-meshheading:7829088-Mice,
pubmed-meshheading:7829088-Molecular Sequence Data,
pubmed-meshheading:7829088-Neoplasms,
pubmed-meshheading:7829088-Polymerase Chain Reaction,
pubmed-meshheading:7829088-Proteins,
pubmed-meshheading:7829088-Sequence Homology, Nucleic Acid,
pubmed-meshheading:7829088-Species Specificity,
pubmed-meshheading:7829088-Trans-Activators,
pubmed-meshheading:7829088-Transcription Factors,
pubmed-meshheading:7829088-beta Catenin
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pubmed:year |
1994
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pubmed:articleTitle |
Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development.
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pubmed:affiliation |
Institut für Humangenetik der Universität, Erlangen, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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