|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0008059,
umls-concept:C0013371,
umls-concept:C0021853,
umls-concept:C0031164,
umls-concept:C0033684,
umls-concept:C0043481,
umls-concept:C0205178,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C1280500,
umls-concept:C1304890,
umls-concept:C1515075,
umls-concept:C1517945,
umls-concept:C2004454
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1995-2-21
|
|
pubmed:abstractText |
The effect of zinc supplementation on intestinal permeability changes and protein loss was studied in 32 children aged between 1 and 12 years during bouts of acute shigellosis and after recovery. An intestinal permeability test and then a 48 hour balance study were performed on all patients. They were then blindly assigned to receive vitamin B syrup either with or without zinc acetate (15 mg/kg per day) for a month. All patients received a five day course of nalidixic acid. The balance study was repeated during convalescence and follow up, but a permeability test was done only at follow up after one month. Intestinal permeability, expressed as a urinary lactulose:mannitol excretion ratio, improved significantly (p = 0.001) along with a significant increase (p = 0.005) in mannitol excretion in the zinc supplemented children, suggesting a resolution of small bowel mucosal damage. The latter was associated with a higher coefficient of nitrogen absorption (p = 0.03), suggesting a possible role of zinc in the treatment of shigellosis. Enteric protein loss, as assessed by faecal alpha 1 antitrypsin clearance, was not influenced by zinc supplementation.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-1090480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-1090770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-1432467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-1781003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-2361756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-300037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-3017238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-3109230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-3283253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-3411389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-3772163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-4032170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-4050425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-4556723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-455691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-6501931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-6513735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-6616939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7829006-6801964
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0017-5749
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
35
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1707-11
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:7829006-Cell Membrane Permeability,
pubmed-meshheading:7829006-Child,
pubmed-meshheading:7829006-Child, Preschool,
pubmed-meshheading:7829006-Double-Blind Method,
pubmed-meshheading:7829006-Dysentery, Bacillary,
pubmed-meshheading:7829006-Female,
pubmed-meshheading:7829006-Humans,
pubmed-meshheading:7829006-Infant,
pubmed-meshheading:7829006-Intestines,
pubmed-meshheading:7829006-Lactulose,
pubmed-meshheading:7829006-Male,
pubmed-meshheading:7829006-Mannitol,
pubmed-meshheading:7829006-Nalidixic Acid,
pubmed-meshheading:7829006-Nitrogen,
pubmed-meshheading:7829006-Protein-Losing Enteropathies,
pubmed-meshheading:7829006-Vitamin B Complex,
pubmed-meshheading:7829006-Zinc
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery: effect of zinc supplementation.
|
|
pubmed:affiliation |
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, Non-P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
