Linked Life Data

7827594

Source:http://linkedlifedata.com/resource/pubmed/id/7827594

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1995-2-23
pubmed:abstractText
Cervical cancer is the second most common malignancy in women worldwide and remains a significant health problem for women, especially minority women in the United States. Despite morbid and costly treatment with whole pelvic radiotherapy, radical surgery, and chemotherapy, the overall survival remains 40%. While the epidemiological risk factors are well known, little is known of the pathobiology of cervical carcinogenesis. Prevention of cervical cancer and its precursors is an important objective. New strategies, both clinical and laboratory based, are desperately needed. Cellular and molecular characteristics of the pathobiology of cervical cancer and its precursors need to be quantified, thereby providing insights into the multistep process of cervical carcinogenesis, identifying those precancerous lesions at high risk for progression to invasion, providing potential targets for intervention, and providing intermediate end point biomarkers for chemopreventive therapies. The premise for this strategy in cervical cancer prevention is that squamous cancers of the female genital tract have a well defined preinvasive stage, and that carcinogenesis is a multistep genetic process which involves increasing dysregulation of proliferation and differentiation as lesions progress from normal to human papillomavirus infected tissue to cervical intraepithelial neoplasia to cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1055-9965
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
619-26
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:articleTitle
The natural history of cervical intraepithelial neoplasia: an argument for intermediate endpoint biomarkers.
pubmed:affiliation
Department of Gynecology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
pubmed:publicationType
Journal Article, Review