rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1995-2-17
|
pubmed:abstractText |
The influence of elevated levels of oleate on insulin-stimulated 3-0-methylglucose transport was assessed in vitro, in isolated skeletal muscle obtained from patients with type 2 (non-insulin-dependent) diabetes mellitus (n = 7) and control subjects (n = 8). An increase in oleate levels from 0.3 to 1.0 mmol/l induced a 3.7-fold increase in the rate of oleate oxidation (P < 0.01) in skeletal muscle from control subjects. However, the rate of insulin-stimulated 3-0-methylglucose transport was not altered in isolated skeletal muscle from the control subjects or the type 2 diabetic patients following exposure to 1.0 mmol/l oleate. This observation indicates that elevation of non-esterified fatty acids to a high physiological level has no inhibitory effect on glucose transport.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0940-5429
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
31
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
169-72
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:7827358-3-O-Methylglucose,
pubmed-meshheading:7827358-Biological Transport,
pubmed-meshheading:7827358-Biopsy,
pubmed-meshheading:7827358-Diabetes Mellitus, Type 2,
pubmed-meshheading:7827358-Fatty Acids, Nonesterified,
pubmed-meshheading:7827358-Female,
pubmed-meshheading:7827358-Humans,
pubmed-meshheading:7827358-Insulin,
pubmed-meshheading:7827358-Male,
pubmed-meshheading:7827358-Methylglucosides,
pubmed-meshheading:7827358-Middle Aged,
pubmed-meshheading:7827358-Muscle, Skeletal,
pubmed-meshheading:7827358-Oleic Acid,
pubmed-meshheading:7827358-Oleic Acids,
pubmed-meshheading:7827358-Reference Values
|
pubmed:year |
1994
|
pubmed:articleTitle |
Effects of non-esterified fatty acids on insulin-stimulated glucose transport in isolated skeletal muscle from patients with type 2 (non-insulin-dependent) diabetes mellitus.
|
pubmed:affiliation |
Department of Clinical Physiology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
|