Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5196
pubmed:dateCreated
1995-2-13
pubmed:abstractText
Multiple endocrine neoplasia types 2A and 2B (MEN2A and MEN2B) and familial medullary thyroid carcinoma are dominantly inherited cancer syndromes. All three syndromes are associated with mutations in RET, which encodes a receptor-like tyrosine kinase. The altered RET alleles were shown to be transforming genes in NIH 3T3 cells as a consequence of constitutive activation of the RET kinase. The MEN2A mutation resulted in RET dimerization at steady state, whereas the MEN2B mutation altered RET catalytic properties both quantitatively and qualitatively. Oncogenic conversion of RET in these neoplastic syndromes establishes germline transmission of dominant transforming genes in human cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
267
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
381-3
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:7824936-3T3 Cells, pubmed-meshheading:7824936-Alleles, pubmed-meshheading:7824936-Animals, pubmed-meshheading:7824936-Cell Transformation, Neoplastic, pubmed-meshheading:7824936-Drosophila Proteins, pubmed-meshheading:7824936-Genetic Vectors, pubmed-meshheading:7824936-Humans, pubmed-meshheading:7824936-Mice, pubmed-meshheading:7824936-Multiple Endocrine Neoplasia Type 2a, pubmed-meshheading:7824936-Multiple Endocrine Neoplasia Type 2b, pubmed-meshheading:7824936-Mutation, pubmed-meshheading:7824936-Phosphorylation, pubmed-meshheading:7824936-Proto-Oncogene Proteins, pubmed-meshheading:7824936-Proto-Oncogene Proteins c-ret, pubmed-meshheading:7824936-Proto-Oncogenes, pubmed-meshheading:7824936-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:7824936-Substrate Specificity, pubmed-meshheading:7824936-Transfection, pubmed-meshheading:7824936-Tumor Cells, Cultured
pubmed:year
1995
pubmed:articleTitle
Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B.
pubmed:affiliation
Centro di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (CNR), Napoli, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't