Linked Life Data

7824558

Source:http://linkedlifedata.com/resource/pubmed/id/7824558

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-2-15
pubmed:abstractText
Twenty-five Sprague-Dawley rats were implanted with electrodes for standard sleep-wake cycle recordings. A guide cannula was stereotaxically implanted into the lateral ventricle. Rats were divided into five groups (n = 5) and challenged with an intraventricular administration of 10 microliters of a 5 nM solution of either: ethanol (EtOH), MK-801, AP5 (noncompetitive and competitive NMDA receptor antagonists, respectively), CNQX (AMPA receptor antagonist), or saline. Rats were recorded polygraphically for the following 4 h. Results showed that, at comparable doses, all tested drugs reduced REM sleep. No significant changes were detected in slow-wave sleep or wakefulness. This selective effect of glutamatergic antagonists suggests that glutamate may be a selective modulator of REM sleep. These findings also show that EtOH shares similar pharmacological effects on the sleep-wake cycle of the rat. Ultimately, glutamatergic mechanisms could contribute to the EtOH-mediated reduction of REM sleep.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
413-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Pharmacology of ethanol and glutamate antagonists on rodent sleep: a comparative study.
pubmed:affiliation
Department of Neuropharmacology CVN-13, Scripps Research Institute, La Jolla, CA 92037.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't